Utjecaj statusa vitamina D u organizmu na tijek infekcije virusom SARS-CoV-2

master's thesis

• Title (english): Influence of vitamin D status in the organism on the course of SARS-CoV-2 infection
• Author: Mia Šimunović
• Mentor: Anita Somborac Bačura (mentor)
• Committee member: Anita Somborac Bačura (predsjednik povjerenstva)
• Committee member: Ivan Pepić (član povjerenstva)
• Committee member: Roberta Petlevski (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medical biochemistry and haematology); Zagreb
• Defense date and country: 2022-11-24, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

SARS-CoV-2 uzročnik je najnovije pandemijske zarazne bolesti, COVID-19, koja predstavlja ozbiljan rizik za ljudsko zdravlje. Infekcija SARS-CoV-2 uzrokuje aktivaciju imunosnog sustava i sustavnu hiperinflamaciju što može dovesti do akutnog respiratornog distres sindroma (ARDS), jednog od vodećih uzroka morbiditeta i mortaliteta u bolesnika s teškim oblikom infekcije SARS-CoV-2. Žrtve ARDS-a karakterizira značajan porast IL-6 i IL-1 te oštećenje endotela i povećana propusnost barijera. Aktivacija makrofaga, povezana s citokinskom olujom, potiče disregulaciju urođenog imuniteta, a u vrlo teškim oblicima infekcije dovodi i do oštećenja te zatajenja brojnih organa. Vitamin D i njegov receptor, receptor vitamina D (VDR), imaju ključnu ulogu u infekcijama zbog svog izvanrednog utjecaja na urođene i stečene imunosne odgovore te na suzbijanje upalnog procesa. Vitamin D smanjuje jačinu citokinske oluje te smanjuje sistemski upalni odgovor stimulirajući diferencijaciju regulatornih T stanica. Također, inducira proizvodnju endogenih antimikrobnih peptida koji organizam štite od napadajućeg respiratornog virusa. Zaštitna svojstva suplementacije vitaminom D potkrijepljena su brojnim opservacijskim studijama i meta-analizom kliničkih ispitivanja za prevenciju virusnih akutnih respiratornih infekcija. Imajući navedeno na umu, preporuča se održavanje optimalne razine vitamina D u krvi jer se time pospješuje rad imunosnog sustava koji omogućuje organizmu da se učinkovito izbori sa svim patogenima, uključujući viruse.

Abstract (english)

SARS-CoV-2 is the causative agent of the latest pandemic infectious disease, COVID-19, which constitues a serious risk to human health. SARS-CoV2 infection causes immune activation and systemic hyperinflammation which can lead to acute respiratory distress syndrome (ARDS), one of the leading causes of morbidity and mortality in patients with a severe form of SARS-CoV-2 infection. ARDS victims are characterized by a significant increase in IL-6 and IL-1, as well as endothelial damage and increased barrier permeability. Macrophage activation, associated with the cytokine storm, promotes dysregulation of innate immunity and in very severe forms of infection leads to damage and failure of numerous organs. Vitamin D and its receptor, vitamin D receptor (VDR), exert a critical role in infections due to their remarkable impact on both innate and adaptive immune responses as well as on the suppression of the inflammatory process. Vitamin D reduces the intensity of the cytokine storm and also reduces the systemic inflammatory response by stimulating the differentiation of regulatory T cells. It also induces the production of endogenous antimicrobial peptides that protect the body from attacking respiratory viruses. The protective properties of vitamin D supplementation have been supported by numerous observational studies and by meta-analysis of clinical trials for prevention of viral acute respiratory infections. Considering this, it is recommended to maintain an optimal level of vitamin D in the blood, as this improves the work of the immune system, which enables the body to effectively fight all pathogens, including viruses.

• Keywords: vitamin D; 1; 25(OH)2D; imunomodulatorni učinci vitamina D; COVID-19; SARS-CoV-2; respiratorne infekcije
• Keywords (english): vitamin D; 1; 25(OH)2D; immunomodulatory effects of vitamin D; COVID-19; SARS-CoV-2; respiratory diseases
• Language: croatian
• URN:NBN: urn:nbn:hr:163:556429
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-11-29 11:40:50