Utjecaj pojedinih čimbenika na pojavnost infekcija dermatofitima

master's thesis

• Title (english): Influence of certain factors on the appearance of dermatophite infections
• Author: Karla Jakšić
• Mentor: Maja Šegvić Klarić (mentor)
• Committee member: Maja Šegvić Klarić (predsjednik povjerenstva)
• Committee member: Maja Ortner Hadžiabdić (član povjerenstva)
• Committee member: Sanja Dabelić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of microbiology); Zagreb
• Defense date and country: 2022-09-26, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Dermatofitoze, gljivične infekcije rožnatog sloja kože, noktiju i kose, jedan su od najčešćih kožnih
oboljenja. Najčešće infekcije izazivaju vrste Epidermophyton, Microsporum i Trichophyton.
Dijagnoza se postavlja na osnovi kliničke slike i analizom strugotina tkiva zahvaćenog infekcijom
(obrada s kalijevim hidroksidom, uzgoj na hranjivoj podlozi, PCR, dermoskopija). Terapija ovisi o
mjestu infekcije i stupnju raširenosti, a standardna terapija su lokalni ili sistemski antimikotici.
Na razvoj dermatofitoza mogu utjecati različiti čimbenici, životne prilike i navike. Provođenje
ankete među pacijentima kod kojih se sumnja na infekciju dermatofitima može značajno pomoći u
postavljanju dijagnoze i liječenju. Stoga je provedeno pilot-istraživanje na 151 ispitaniku kako bi
se vidio utjecaj raznih čimbenika na povećanu učestalost dermatofitoza kod ljudi i koji su to točno
čimbenici. Rezultati ovog rada su temelj za provođenje šireg epidemiološkog istraživanja
raznolikosti vrsta dermatofita u onihomikozama u različitim županijama Hrvatske.

Abstract (english)

Dermatophytoses, fungal infections of the stratum corneum of the skin, nails and hair, are one of
the most common skin diseases. The most common infections are caused by Epidermophyton,
Microsporum and Trichophyton. The diagnosis is made on the basis of the clinical picture and the
analysis of tissue scraps affected by the infection (treatment with potassium hydroxide, growth on
a nutrient medium, PCR, dermoscopy). Therapy depends on the site of infection and the degree of
spread. Standard therapy is local or systemic antimycotics. The development of dermatophytosis
can be influenced by various factors, life circumstances and habits. Conducting a survey of
patients with suspected dermatophyte infection can significantly aid in diagnosis and treatment.
Therefore, a pilot study was conducted on 151 subjects in order to see the influence of various
factors on the increased frequency of dermatophytoses in humans and what exactly these factors
are. The results of this work are the basis for conducting a wider epidemiological study of the
diversity of dermatophyte species in onychomycosis in different counties of Croatia.

• Keywords: dermatofiti; dermatofitoza; infekcija; tinea; Trichophyton; Epidermophyton; Microsporum; polimerazna lančana reakcija; PLR; antifungalna terapija
• Keywords (english): dermatophytes; dermatophytosis; infection; tinea; Trichophyton; Epidermophyton; Microsporum; polymerase chain reaction; PCR; antifungal therapy
• Language: croatian
• URN:NBN: urn:nbn:hr:163:880912
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-12-01 10:22:02