Bioaktivne biljne sastavnice i mikronutrijenti za ublažavanje simptoma endometrioze

professional thesis

• Author: Petra Filipović Radošević
• Mentor: Sanda Vladimir-Knežević (mentor)
• Committee member: Dubravka Vitali Čepo (predsjednik povjerenstva)
• Committee member: Sanda Vladimir-Knežević (član povjerenstva)
• Committee member: Irena Vedrina-Dragojević (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2022-02-04, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj istraživanja
Cilj ovog specijalističkog rada je dati sveobuhvatan pregled znanstvenih spoznaja o učincima i mehanizmima djelovanja bioaktivnih biljnih sastavnica i mikronutrijenata na ublažavanje simptoma endometrioze kako bi se prema znanstveno utemeljenim dokazima mogli donijeti relevantni zaključci o njihovom potencijalu terapijske primjene.
Materijali i metode
Istraživanje u okviru specijalističkog rada je teorijskog karaktera i uključuje pregled dostupne stručne i znanstvene literature o predloženoj temi. Pretražene su dostupne elektronske baze podataka na engleskom jeziku: PubMed, Scopus, ScienceDirect, Cochrane. Prikupljeni podaci obuhvatili su pretklinička i klinička ispitivanja koja su zatim sistematično prikazana.
Rezultati
U sklopu ovog specijalističkog rada prikazani su rezultati nekliničkih i manje brojnih kliničkih istraživanja kurkumina, resveratrola, epigalokatehin-3-galata, krocina i genisteina te ekstrakata konopljikina ploda, vrkutine zeleni i kore primorskog bora. Bioaktivne biljne sastavnice i biljni ekstrakti razmatrani u ovom radu pokazali su antiproliferativne, proapoptotske, antiangiogenetske, protuupalne i antioksidacijske učinke u uvjetima in vitro i in vivo. Istaknut je potencijal alfa-lipoične kiseline, vitamina C, E i D, melatonina te akupunkture i višekomponentnih smjesa tradicionalne kineske medicine. No, postojeći klinički dokazi nedovoljno podupiru njihovu praktičnu primjenu za ublažavanje simptoma endometrioze.
Zaključci
Iako razina kliničkih dokaza o djelovanju bioaktivnih biljnih sastavnica i mikronutrijenata u endometriozi nije zadovoljavajuća, tradicionalna primjena i dosadašnje znanstvene spoznaje ukazuju na njihov veliki potencijal i ohrabruju daljnja klinička istraživanja.

Abstract (english)

Objectives
The objective of this research is to provide a comprehensive overview of scientific knowledge on the effects and mechanisms of action of bioactive plant components and micronutrients on the alleviation of endometriosis symptoms in order to draw relevant conclusions about their potential for therapeutic application.
Materials and methods
Research in this paper is a theoretical one and includes a detailed overview of the available professional and scientific data on the topic. Relevant bibliographic database in English language, such as PubMed, Scopus, ScienceDirect and Cochrane were searched. The collected data included preclinical and clinical trials, which were then presented systematically.
Results
This work presents the results of nonclinical and a small number of clinical studies of curcumin, resveratrol, epigallocatechin-3-gallate, crocin, genistein and extracts of Agnus castus fruit, Alchemilla and French maritime pine bark. The bioactive plant components and plant extracts considered in this work demonstrated in vitro and in vivo antiproliferative, proapoptotic, antiangiogenic, anti-inflammatory and antioxidant effects. The potential of alpha-lipoic acid, vitamins C, E and D, melatonin, acupuncture and multi-component mixtures of TCM was also highlighted. However, the clinical evidence does not sufficiently support their practical application to alleviate the symptoms of endometriosis.
Conclusion
Although the level of clinical evidence on the effect of bioactive plant components and micronutrients in endometriosis is insufficient, traditional use and current scientific knowledge indicate their great potential and encourage further clinical research.

• Keywords: bioaktivne biljne sastavnice; biljni ekstrakti; mikronutrijenti; endometrioza
• Keywords (english): bioactive plant components; plant extracts; micronutrients; endometriosis
• Language: croatian
• URN:NBN: urn:nbn:hr:163:126070
• Study programme: Title: Phytopharmacy with dietotherapy; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni magistar/sveučilišna magistra fitofarmacije s dijetoterapijom (sveučilišni magistar/sveučilišna magistra fitofarmacije s dijetoterapijom)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-02-16 14:39:03