Priprava i profil oslobađanja timolola uklopljenog u micele neionskih površinski aktivnih tvari

master's thesis

• Title (english): Preparation and profile release of timolol integrated into micelles of nonionic surfactants
• Author: Ivona Ivančić
• Mentor: Ivan Pepić (mentor)
• Committee member: Ivan Pepić (predsjednik povjerenstva)
• Committee member: Iva Mucalo (član povjerenstva)
• Committee member: Lovorka Vujić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2016-04-08, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

U ovom radu ispitano je uklapanje i oslobađanje timolola iz micela Pluronic F68 i tiloksapola u Krebs-Ringerovom puferu pH=7,4 kao složenoj otopini elektrolita pri 25°C postupkom dijalize u uvjetima osigurane topljivosti.Količina oslobođenog timolola određena je spektrofotometrijski pri  = 295 nm. Veličina i raspodjela veličina micela ne mijenja se znatno pri uklapanju timolola. Moguće je zaključiti da uklapanje timolola u micele Pluronic F68 ili tiloksapola ne utječe na fizičku stabilnost i stvaranje micela
procesom samoorganiziranja.Opaženo je ubrzanje oslobađanja timolola iz Pluronic F68 i tiloksapol micela pri koncentracijama od 0,1%. Dok pri kocentracija 0,5% i 1% Pluronica F68 ili tiloksapola nije došlo do ubrzanja oslobađanja timolola. Takvi rezultati ukazuju na djelomično uklapanje timolola u omotač micela Pluronica F68 ili tiloksapola s vrlo vjerojatnom brzom raspodjelom timolola između micelarne i vodene faze.

Abstract (english)

In this study examined the incorporation and release of timolol from the micelles tyloxapol and Pluronic F68 in a Krebs-Ringer buffer pH 7,4 as a complex solution of electrolyte at 25 ° C in a dialysis process under conditions provided solubility.The amount of released timolol was determined spectrophotometrically at  = 295 nm.The size and size distribution of micelles does not change significantly in adapting timolol. It is possible to conclude that the integration of timolol in micelles Pluronic F68 or tyloxapol does not affect the physical stability and a micelle-forming process of selforganization. It was observed acceleration of release of timolol from Pluronic F68 and tyloxapol micelles at
concentrations of 0.1%. While the concentration are 0.5% and 1% Pluronic F68 tyloxapol or not an acceleration of release of timolol.These results indicate a partial integration of timolol in the micelle shell Pluronic F68 or tyloxapol with a probable rapid distribution of timolol between micellar and aqueous phases.

• Keywords: timolol; tiloksapol; Pluronic F68
• Keywords (english): timolol; tyloxapol; Pluronic F68
• Language: croatian
• URN:NBN: urn:nbn:hr:163:516439
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-06-06 15:52:24