Primjena topikalnih retinoida kod fotostarenja kože

master's thesis

• Title (english): The use of topical retinoids in skin photoaging
• Author: Sara Senčar
• Mentor: Ivan Pepić (mentor)
• Committee member: Ivan Pepić (predsjednik povjerenstva)
• Committee member: Dubravka Vitali Čepo (član povjerenstva)
• Committee member: Laura Nižić Nodilo (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2023-06-30, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Starenje kože je multisistemski proces koji započinje sredinom dvadesetih godina. Razlikuje se
intrinzično i ekstrinzično starenje. Intrinzično (kronološko) starenje je prirodan proces, dok je
ekstrinzično uvjetovano vanjskim čimbenicima te se često naziva i fotostarenje. Fotostarenje kože
je izravno u korelaciji s izlaganjem UV zračenju tijekom života te se uglavnom ispoljava prije nego
kronološko starenje. Fotooštećenu kožu karakteriziraju hiperpigmentacijske mrlje, opadanje razine
kolagena i elastina te bore. Pojedincima koji više vremena provode na otvorenom, svijetle su puti ili
pak žive u sunčanom podneblju koža brže stari. Kako bi se preveniralo oštećenje kože uzrokovano
UV zračenjem koriste se proizvodi sa zaštitnim faktorom. Razlikuju se proizvodi s kemijskim i
mineralnim filterima koji se mogu naći u različitim kozmetičkim oblicima (npr. krema, fluid, losion,
mlijeko). U svrhu prevencije i usporavanja fotostarenja koriste se proizvodi koji sadrže vitamin C,
azelaičnu kiselinu te retinoide. Studije potvrđuju kako su kod fotostarenja najučinkovitiji retinoidi.
Najviše se koriste tretinoin, retinol i retinal. Potrebno ih je uvoditi s oprezom zbog moguće
retinoidne reakcije koju karakteriziraju svrbež, crvenilo i ljuskanje kože. Trudnicama, dojiljama i
ženama koje planiraju trudnoću ne preporuča se korištenje retinoida zbog teratogenog djelovanja te
se sugerira korištenje glikolne kiseline, vitamina C te bakuchiola.

Abstract (english)

Skin aging is a multisystemic process that begins in the mid-twenties. We differentiate intrinsic and
extrinsic aging. Intrinsic (chronological) aging is a natural process, while extrinsic aging is
conditioned by external factors and is often called photoaging. Photoaging of the skin is directly
correlated with the amount of UV rays exposed during life and is generally manifested earlier than
chronological aging. Photodamaged skin is characterized by hyperpigmentation spots, decreasing
levels of collagen and elastin, and wrinkles. Individuals's skin who spend more time outside, have
fair skin, or live in sunny climates ages faster. In order to prevent skin damage caused by UV rays,
products with a protective factor are used. We distinguish between products with chemical and
mineral filters that can be found in different cosmetic forms (eg cream, fluid, lotion, milk, etc.). In
order to prevent and treat photoaging, products containing vitamin C, azelaic acid and retinoids are
used. Studies confirm that retinoids are the most effective in photoaging. The most commonly used
are tretinoin, retinol and retinal. They should be introduced with caution due to a possible retinoid
reaction characterized by itching, redness and scaling of the skin. Pregnant women, lactating women
and women planning to become pregnant are advised to avoid the use of retinoids due to their
teratogenic effect, and the use of glycolic acid, vitamin C and bakuchiol is suggested.

• Keywords: retinoidi; topikalni retinoidi; starenje kože; ekstrinzično starenje; fotostarenje
• Keywords (english): retinoids; topical retinoids; skin aging; extrinsic aging; photoaging
• Language: croatian
• URN:NBN: urn:nbn:hr:163:020836
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-11-17 10:25:07