Određivanje etilen oksida u dodacima prehrani koji se koriste za liječenju upalne bolesti crijeva

master's thesis

• Title (english): Quantification of ethylene oxide in dietary supplements used for treatment of inflammatory bowel diseases
• Author: Jure Potočnjak
• Mentor: Ana Mornar Turk (mentor)
• Committee member: Ana Mornar Turk (predsjednik povjerenstva)
• Committee member: Daniela Amidžić Klarić (član povjerenstva)
• Committee member: Goran Poje (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical analysis); Zagreb
• Defense date and country: 2023-06-30, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Etilen oksid kemijski je spoj otkriven još početkom 20. stoljeća te se od tada njegova primjena počela
širiti, a glavnu ulogu pronašao je u niskotemperaturnom sterilizacijskom procesu koji se primjenjuje
za sterilizaciju medicinske opreme, farmaceutskih i prehrambenih sirovina i materijala. Polovicom
20. stoljeća postalo je jasno kako ovaj spoj nije bezopasan te da se njegova primjena i koncentracija
u sirovinama mora strogo regulirati. Brojne znanstvene studije ukazuju na to da etilen oksid ima
karcinogeno, mutageno i reproduktivno toksično djelovanje zbog čega je javnost postala sve više
zabrinuta i skeptična u pogledu primjene ovog sterilizacijskog agensa.
Istraživanje, koje je provedeno na Zavodu za analitiku i kontrolu lijekova Farmaceutsko –
biokemijskog fakulteta Sveučilišta u Zagrebu, temelji se na analizi 53 različita uzorka dodataka
prehrani nabavljenih u Europi i ostatku svijeta. Rezultati istraživanja su, na žalost, poražavajući jer
je čak preko polovine analiziranih uzoraka sadržavalo detektabilne razine etilen oksida, dok je 8
uzoraka sadržavalo razine etilen oksida veće od 0.1mg/kg, što je gornja dozvoljena granica
koncentracije rezidua etilen oksida u Europskoj uniji. Čak 2 uzorka sadržavala su 30 puta veće razine
etilen oksida od dopuštenih.
Ovo istraživanje ima za cilj ukazati regulatornim tijelima Europske unije i cijelog svijeta na štetnost
ovog spoja i potrebu za strožim nadzorom farmaceutskih, prehrambenih, tekstilnih i drugih sirovina
kod kojih se koristi oblik sterilizacije etilen oksidom.

Abstract (english)

Ethylene oxide is chemical compound that is discovered at the begining of 20th century and, since
that, its application started spreading, but the main application it found in low-temperature
sterilisation process that is used for sterilisation of medical equipment, farmaceutical materials and
food products. At the half of 20th century, people found out that this compound is not so safe for
human health, so health organisations started exercise control of concentrations of ethylene oxide in
raw materials that were sterilised with this compund. Numerous scientific researchs indicate that
ethylene oxide has carcinogenic and mutagenic impact, and also is considered as reproductive toxic
agent. That is the reason why so many people are concerned about using ethylene oxide as
sterilisation agent.
Research, that is conducted on the Institute for drug analysis and control on Faculty of Pharmacy
and Medical Biochemistry of the University of Zagreb, is based on the analysis of 53 different
samples of dietary supplements that are found in Europe and in the rest of the world. Results of the
research are, unfortunately, devastating because there were more than a half of 53 samples that had
detectabile ethylene oxide concentrations in their composition. 8 of them had ethylene oxide
concentrations that are more than allowed in the European Union (0.1mg/kg). Furthermore, 2 of the
samples had ethylene oxide concentrations that were 30 times more than allowed in the EU.
The purpose of tihs research is to indicate to the regulatory authorities of the EU and the rest of the
world that ethylene oxide is very toxic compound and that there should be stricter surveillance of
pharmaceutical, textile, food and other materials that pass through ethylene oxide sterilisation
process.

• Keywords: etilen oksid; dodaci prehrani; upalna bolest crijeva
• Keywords (english): ethylene oxide; dietary supplements; inflammatory bowel disease
• Language: croatian
• URN:NBN: urn:nbn:hr:163:945527
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-11-17 10:50:34