Nuspojave i terapijske mogućnosti zbrinjavanja nuspojava zračenja u pacijentica koje su preboljele hormonski ovisan karcinom dojke

master's thesis

• Title (english): Side effects and therapeutic options for treating side effects of radiation in patients who have recovered from hormone-dependent breast cancer
• Author: Kristina Špiček
• Mentor: Iva Mucalo (mentor)
• Mentor: Tajana Silovski (mentor)
• Committee member: Iva Mucalo (predsjednik povjerenstva)
• Committee member: Tajana Silovski (član povjerenstva)
• Committee member: Lidija Bach-Rojecky (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Centre for applied pharmacy); Zagreb
• Defense date and country: 2023-06-07, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Karcinom dojke najčešća je maligna bolest u žena i vodeći uzročnik smrtnosti. Liječenje uključuje
operativni zahvat, radioterapiju, kemoterapiju, endokrinu terapiju, imunoterapiju odnosno
kombinaciju pojedinih navedenih terapija, sukladno propisanim smjernicama. Odluka o vrsti
terapije temeljena je na nalazu stadija karcinoma, općem stanju pacijenta, dobi i komorbiditetima.
Radioterapija se primjenjuje nakon poštednog operativnog zahvata ili mastektomije, s ciljem
povećanja ukupnog i specifičnog preživljenja te smanjenja rizika relapsa bolesti. Suvremene
radiološke tehnike apliciraju dozu zračenja na ciljano područje, uz značajnu poštedu izloženih
organa. Preporučuje se provesti terapiju zračenjem 4 tjedna po operaciji, odnosno 4 tjedna od
primijenjene kemoterapije. Nuspojave radioterapije mogu izazvati akutnu toksičnost ozračenog
područja, ali i kronične komplikacije, koje se javljaju i nekoliko godina po završenoj terapiji
zračenjem. Iste se tretiraju farmakološki i simptomatsko-suportivnim mjerama, a liječenje provodi
multidisciplinarni tim.

Abstract (english)

Breast cancer is the most common malignant disease in women and the leading cause of death.
Treatment includes surgery, radiotherapy, chemotherapy, endocrine therapy, immunotherapy, or a
combination of the above-mentioned therapies, in accordance with the prescribed guidelines. The
decision on the type of therapy is based on the finding of the cancer stage, patient's general condition,
age and comorbidities. Radiotherapy is applied following sparing surgery or mastectomy, with the
aim of increasing overall and specific survival and reducing the risk of disease relapse. Modern
radiological techniques apply a dose of radiation to the target area, with significant sparing of the
exposed organs. It is recommended to carry out radiation therapy 4 weeks after the surgery, i.e. 4
weeks after chemotherapy. The side effects of radiotherapy can cause acute toxicity of the irradiated
area, but also chronic complications, which occur several years after the end of radiation therapy.
They are treated with pharmacological and symptomatic-supportive measures, and the treatment is
carried out by a multidisciplinary team.

• Keywords: karcinom dojke; liječenje; radioterapija; radiološke tehnike; nuspojave
• Keywords (english): breast cancer; treatment; radiotherapy; radiological techniques; side effects
• Language: croatian
• URN:NBN: urn:nbn:hr:163:779833
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-01-04 14:38:25