Dodaci prehrani u žena koje su preboljele hormonski ovisan karcinom dojke

master's thesis

• Title (english): Dietary supplements in women who have overcome hormone-dependent breast cancer
• Author: Amela Mašinović
• Mentor: Iva Mucalo (mentor)
• Committee member: Iva Mucalo (predsjednik povjerenstva)
• Committee member: Lidija Bach-Rojecky (član povjerenstva)
• Committee member: Ivana Perković (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Centre for applied pharmacy); Zagreb
• Defense date and country: 2024, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Dodaci prehrani definirani su kao pojedinačni ili kombinirani izvori hranjivih tvari namijenjeni za nadoknadu esencijalnih mikronutrijenata u svakodnevnoj prehrani u svrhu unaprjeđivanja ili održavanja zdravlja što je posebno važno za pacijente oboljele od malignih bolesti u čijoj je populaciji i zabilježena učestalija primjena dodataka prehrani. Iako dodaci prehrani imaju mnoge dobrobiti, postoji opravdana zabrinutost da njihova primjena može utjecati na učinkovitost kemoterapije i radioterapije. Tako primjerice antioksidansi mogu smanjiti učinak kemoterapije i radioterapije interferiranjem s reaktivnim kisikovim spojevima koji induciraju apoptozu tumorskih stanica, a primjena nezasićenih masnih kiselina može se povezati sa smanjenjem ukupne smrtnosti. U ovom istraživanju sudjelovalo je 310 pacijentica dobi od 27 do 91 godine, a cilj je bio ispitati navike primjene dodataka prehrani u populaciji pacijentica oboljelih od hormonski ovisnog raka dojke. Utvrđeno je da je primjena učestalija u pacijentica starije životne dobi i višeg stupnja obrazovanja. U primjeni su većinom dodaci prehrani jednostavnijeg sastava bez posebnog učinka na nuspojave terapije ili prevenciju samog raka dojke iz čega se može zaključiti da njihov potencijal nije iskorišten.

Abstract (english)

Dietary supplements are defined as individual or combined sources of nutrients intended for the replacement of essential micronutrients in the daily diet for the purpose of improving or maintaining health, which is especially important for patients suffering from malignant diseases in whose population more frequent use of dietary supplements has been recorded. Although dietary supplements have many benefits, there is a legitimate concern that their use may affect the effectiveness of chemotherapy and radiotherapy. For example, antioxidants can reduce the effect of chemotherapy and radiotherapy by interfering with reactive oxygen compounds that induce apoptosis of tumor cells, and the use of unsaturated fatty acids can be associated with a reduction in overall mortality. 310 patients between the ages of 27 and 91 participated in this study, and the goal was to examine the habits of using dietary supplements in the population of patients with hormone-dependent breast cancer. It was found that the application is more frequent in patients of an older age and a higher level of education. Most of the food supplements in use are of simpler composition without any special effect on the side effects of therapy or the prevention of breast cancer itself, from which it can be concluded that their potential has not been used.

• Keywords: hormonski ovisan rak dojke; dodaci prehrani; endokrina terapija
• Keywords (english): hormone dependent breast cancer; food supplements; endocrine therapy
• Language: croatian
• URN:NBN: urn:nbn:hr:163:245660
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-01-22 13:18:49