Potencijal kratoma u liječenju nociceptivne boli

master's thesis

• Title (english): The potential of kratom in the treatment of nociceptive pain
• Author: Kristina Mijić
• Mentor: Marijana Zovko Končić (mentor)
• Committee member: Marijana Zovko Končić (predsjednik povjerenstva)
• Committee member: Maja Bival Štefan (član povjerenstva)
• Committee member: Lidija Bach-Rojecky (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2023-09-08, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Kratom je biljka s dugom povijesti tradicijskog korištenja kod brojnih stanja pri čemu je
često droga izbora za samoliječenje boli. Cilj ovog diplomskog rada je bio prikupiti relevantne
pretkliničke in vivo i kliničke studije koje su proučavale analgetsko djelovanje ekstrakata
kratoma, njegovih alkaloida (mitragina, 7-hidroksimitraginina) i polusintetskih derivata,
razjasniti mehanizam djelovanja i procijeniti ima li potencijal da postane novi legalni analgetik.
Zbog uočene povezanosti dugotrajne primjene kratoma s razvojem ovisnosti, diplomski rad je
baziran samo na liječenju boli nociceptivnog tipa. Sve studije koje su uključene u diplomski rad
su potvrdile kako ekstrakti, izolirani alkaloidi i njihovi polusintetski derivati kratoma posjeduju
analgetska svojstva. Ovim sustavnim pregledom je ustanovljeno da su analgetski učinci
posredovani uglavnom opioidnim sustavom i da to može postati sigurnosti problem kod primjene.
Unatoč tome, ovaj rad nudi dokaze da postoji potencijal da jedan od alkaloida kratoma ili pak
spoj polusintetiziran iz tih alkaloida postane analgetik koji bi bio učinkovitiji i sigurniji u odnosu
na morfin.

Abstract (english)

Kratom is a plant with a long history of traditional use for numerous conditions, often being
the drug of choice for self-treatment of pain. The aim of this thesis was to collect relevant
preclinical in vivo and clinical studies that investigated the analgesic effect of kratom extracts, its
alkaloids (mitragynine, 7-hydroxymitragynine) and semi-synthetic derivatives, clarify the
mechanism of action and assess whether it has the potential to become a new legal analgesic. Due
to the observed association of long-term use of kratom with the development of addiction, the
thesis is based only on the treatment of pain of the nociceptive type. All studies that are included
in the thesis confirmed that extracts, isolated alkaloids and their semi-synthetic derivatives of
kratom possess analgesic properties. In this systematic review, it was found that the analgesic
effects are mediated mainly by the opioid system and that this may become a safety issue in
administration. Nevertheless, this thesis offers evidence that there is a potential for one of the
kratom alkaloids or a compound semi-synthesized from these alkaloids to become an analgesic
that would be more effective and safer than morphine.

• Keywords: kratom; M. speciosa; analgezija; antinocicepcija; nociceptivna bol
• Keywords (english): kratom; M. speciosa; analgesia; antinociception; nociceptive paik
• Language: croatian
• URN:NBN: urn:nbn:hr:163:708395
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-01-24 14:59:29