Analiza farmaceutskih proizvoda rendgenskom fluorescencijskom spektroskopijom s totalnom refleksijom: osnovni principi i analitički postupci

master's thesis

• Title (english): Total reflection X-ray fluorescence analysis of pharmaceutical products: basic principles and analytical procedures
• Author: Tamara Fruk
• Mentor: Jasna Jablan (mentor)
• Committee member: Jasna Jablan (predsjednik povjerenstva)
• Committee member: Suzana Inić (član povjerenstva)
• Committee member: Maja Bival Štefan (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of analytical chemistry); Zagreb
• Defense date and country: 2023-09-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Elementarna onečišćenja mogu dospjeti u farmaceutski proizvod u raznim fazama njegovog razvoja,
transporta i skladištenja te utjecati na djelatnu tvar, stabilnost farmaceutskog proizvoda ili sama
imati neželjene učinke na ljudsko zdravlje. Zbog toga je elementarna analiza ovakvih uzoraka i
određivanje elementarnih onečišćenja od velikog značaja te postoji potreba za brzim i osjetljivim
analitičkim tehnikama koje se mogu koristiti za takve analize. Uz to, teži se da tehnike slijede načela
„zelene kemije“. U tom smislu, TXRF se nameće kao jedna važna tehnika za kvalitativnu i
kvantitativnu elementarnu analizu. TXRF je spektroskopska tehnika koja se temelji na principu
totalne refleksije rendgenskih zraka, a zbog male količine uzorka potrebnog za analizu, IUPAC
definira TXRF kao tehniku mikroanalize. Znanstvena istraživanja o primjeni TXRF tehnike u analizi
farmaceutskih uzoraka kao što su djelatne tvari, lijekovi i dodaci prehrani pokazuju potencijal
njezine primjene za analizu takvih uzoraka, a kod TXRF tehnike vidljiva je primjena načela zelene
kemije jer je za analizu potrebna mala količina uzorka i reagensa, smanjena je uporaba štetnih
kemikalija i količine energije te se stvara manje štetnog otpada.

Abstract (english)

Elemental impurities may enter the pharmaceutical product at various stages of development,
transportation and storage and may affect the active pharmaceutical ingredient and stability of the
pharmaceutical product or have adverse effects on human health. For this reason, elemental analysis
of these samples and the determination of elemental impurities is of great importance, and there is a
need for fast and sensitive analytical techniques that can be used for such analysis. Moreover, the
methods should comply with the principles of "green chemistry". In this sense, TXRF is presented
as one important technique for qualitative and quantitative elemental analysis. TXRF is a
spectroscopic technique based on the principle of total reflection of X-rays. Because a small amount
of sample is required for analysis, IUPAC defines TXRF as a microanalysis technique. Scientific
studies on the application of TXRF technique in the analysis of pharmaceutical samples such as
active pharmaceutical ingredients, drugs and dietary supplements demonstrate the potential of its
use in the analysis of such samples. The application of „green chemistry“ principles to the TXRF
technique is evident in the small amount of samples and reagents required for analysis, the use of
less harmful chemicals and energy and the generation of less harmful waste.

• Keywords: TXRF; farmaceutski uzorci; elementarne nečistoće; multielementarna analiza
• Keywords (english): TXRF; pharmaceutical samples; elemental impurities; multielemental analysis
• Language: croatian
• URN:NBN: urn:nbn:hr:163:934053
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2025-09-13
• Created on: 2024-01-25 13:28:03