Izazovi u formulaciji multivitaminsko-mineralnih pripravaka

master's thesis

• Title (english): Challenges in the formulation of multivitamin-mineral preparations
• Author: Lorena Vidović
• Mentor: Kristina Radić (mentor)
• Committee member: Kristina Radić (predsjednik povjerenstva)
• Committee member: Dubravka Vitali Čepo (član povjerenstva)
• Committee member: Petra Turčić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of food chemistry); Zagreb
• Defense date and country: 2023-08-28, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Formulacija multikomponentnih pripravaka, poput multivitaminsko-mineralnih pripravaka (MVMP-a), predstavlja iznimno složen proces zbog velikog broja sastojaka s različitim fizikalno-kemijskim svojstvima. Najznačajniji izazovi u formulaciji uključuju topljivost, stabilnost i međusobne interakcije sastojaka. Stabilnost vitamina, posebno vitamina C (askorbinske kiseline), može biti narušena tijekom proizvodnog postupka i skladištenja pripravka. Dodavanje antioksidansa u formulaciju može spriječiti promjenu boje askorbinske kiseline uslijed oksidacije. Primjena odgovarajućih proizvodnih postupaka, poput smanjenja ukupne količine vode u pripravku ili liofilizacije, te keliranje minerala, pridonosi povećanju stabilnosti MVMP-a. Također, dodatak emulgatora i adsorbensa osigurava pravilno uklapanje vitamina topivih u vodi i mastima u MVMP. Kako bi se prikrili neugodni okusi minerala, provode se postupci oblaganja, enkapsulacije i upotreba kelirajućih agensa. Razumijevanje učinka pojedinih sastojaka i osnovnih izazova u formulaciji MVMP-a ključno je za pružanje utemeljenih preporuka, učinkovitu edukaciju, informirane odluke o upotrebi MVMP-a i osiguravanje sigurnosti pacijenata.

Abstract (english)

The formulation of multicomponent preparations, such as multivitamin-mineral preparations (MVMP), is an exceptionally complex process because of the large number of ingredients with different physical and chemical properties. The most significant challenges in formulation include solubility, stability, and interactions between the ingredients. The stability of vitamins, especially vitamin C (ascorbic acid), can be impaired during the production and storage of the preparation. The addition of antioxidants to the formulation can prevent the discoloration of ascorbic acid due to oxidation. The use of appropriate production procedures, such as reducing the total amount of water in the preparation or lyophilization, as well as mineral chelation, contributes to increasing the stability of MVMP. Also, the addition of emulsifiers and adsorbents ensures proper incorporation of water-soluble and fat-soluble vitamins into MVMP. Coating, encapsulation, and the use of chelating agents are used to mask the unpleasant taste of minerals. Understanding the effect of individual ingredients and the main challenges in MVMP formulation is critical for providing evidence-based recommendations, effective education, informed decisions about MVMP use and ensuring patient safety.

• Keywords: multivitaminsko-mineralni pripravci; formulacija multivitaminsko-mineralnih pripravaka; topljivost; stabilnost; međusobne interakcije
• Keywords (english): multivitamin-mineral preparations; formulation of multivitamin-mineral preparations; solubility; stability; mutual interactions
• Language: croatian
• URN:NBN: urn:nbn:hr:163:414428
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-03-21 12:41:06