Terapija visceralne preosjetljivosti u sindromu iritabilnog crijeva

master's thesis

• Title (english): Therapy of visceral hypersensitivity in irritable bowel syndrome
• Author: Stela Vukoja
• Mentor: Lidija Bach-Rojecky (mentor)
• Committee member: Lidija Bach-Rojecky (predsjednik povjerenstva)
• Committee member: Sandra Šupraha-Goreta (član povjerenstva)
• Committee member: Iva Mucalo (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology); Zagreb
• Defense date and country: 2023-08-29, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Visceralna preosjetljivost je važna komponenta sindroma iritabilnog crijeva, a pogađa 30-60% pacijenata, pretežito mlađe dobi i ženskog spola. Patofiziološka podloga visceralne preosjetljivosti nije još do kraja objašnjena, no smatra se da razni periferni i središnji faktori, poput psihološkog stresa i poremećaja crijevne permeabilnosti, mogu uzrokovati promjenu dvosmjerne signalizacije osi crijeva-mozak i povećanu senzitizaciju perifernog (enteričkog) i središnjeg živčanog sustava. Spazmolitici kao periferni neuromodulatori koriste se za smanjenje spazama i abdominalne boli. Antidepresivi se danas najčešće koriste kao središnji neuromodulatori, a istražuju se i atipični antipsihotici. Ovi lijekovi svojim kompleksnim djelovanjem na serotoninski i druge neurotransmitorske sustave djeluju izravno i posredno na neke patofiziološke komponente u podlozi visceralne preosjetljivosti, a posebno su korisni kod pacijenata s psihičkim poremećajima u anamnezi. U raznim studijama, tvari prirodnog porijekla poput berberina i kurkumina, kao i probiotici, pokazuju učinkovitost u smanjenju visceralne preosjetljivosti, što zahtijeva daljnja istraživanja. Istraživanja ukazuju na širok spektar medijatora i receptora uključenih u transmisiju, percepciju i modulaciju bolnih signala porijeklom iz gastrointestinalnog trakta, posebice na razini komunikacije crijeva-mozak, koji se istražuju kao potencijalne nove mete za specifičnije lijekove s neuromodulatornim djelovanjem na visceralnu preosjetljivost.

Abstract (english)

Visceral hypersensitivity is an important component of irritable bowel syndrome, and affects 30-60% of patients, mostly younger and female. The pathophysiological basis of visceral hypersensitivity has not yet been fully explained, but it is believed that various peripheral and central factors, such as psychological stress and disorders of intestinal permeability, can cause a change in the bidirectional signaling of the gut-brain axis and increased sensitization of the peripheral (enteric) and central nervous system. Antispasmodics as peripheral neuromodulators are used to reduce spasms and abdominal pain. Today, antidepressants are most often used as central neuromodulators, and atypical antipsychotics are also being investigated. With their complex action on serotonin and other neurotransmitter systems, these drugs act directly and indirectly on some pathophysiological components underlying visceral hypersensitivity, and are especially useful in patients with a history of mental disorders. In various studies, substances of natural origin such as berberine and curcumin, as well as probiotics, show efficacy in reducing visceral hypersensitivity, which requires further research. Research indicates a wide spectrum of mediators and receptors involved in the transmission, perception and modulation of pain signals originating from the gastrointestinal tract, especially at the level of gut-brain communication, which are being investigated as potential new targets for more specific drugs with neuromodulatory effects on visceral hypersensitivity.

• Keywords: visceralna preosjetljivost; visceralna bol; sindrom iritabilnog crijeva; patofiziologija; farmakoterapija; senzitizacija; crijevni živčani sustav; neuromodulatori; os mozak-crijeva; antidepresivi; psihotropna sredstva; spazmolitici
• Keywords (english): visceral hypersensitivity; visceral pain; irritable bowel syndrome; pathophysiology; pharmacotherapy; sensitization; enteric nervous system; neuromodulators; brain-gut axis; antidepressants; psychotropic agents; spasmolytics
• Language: croatian
• URN:NBN: urn:nbn:hr:163:722888
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-03-21 12:54:44