Povezanost cirkadijalnog ritma s kroničnim bolestima i djelovanjem lijekova

master's thesis

• Title (english): Association between circadial rhythm, cronic diseases and the drug actions
• Author: Jelena Turudić
• Mentor: Lidija Bach-Rojecky (mentor)
• Committee member: Lidija Bach-Rojecky (predsjednik povjerenstva)
• Committee member: Sandra Šupraha-Goreta (član povjerenstva)
• Committee member: Jasna Jablan (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology); Zagreb
• Defense date and country: 2023-06-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

U ovom diplomskom radu opisani su mehanizmi utjecaja cirkadijalnog ritma na farmakokinetske
karakteristike lijekova te povezanost abnormalnosti cirkadijalnog ritma s razvojem kroničnih
bolesti poput hipertenzije, astme i šećerne bolesti. Cirkadijalni ritam razvijen je evolucijski u
većini živih organizama kao odgovor na ponavljajuće dnevne promjene u okolišnim čimbenicima.
Središnji regulatorni „sat“ čini suprahijazmatska jezgra u hipotalamusu, dok se periferni „satovi“
nalaze u stanicama perifernih tkiva te međusobno komuniciraju putem živčanih i humoralnih
signala. Cirkadijalni ritam pomaže u održavanju homeostaze organizma na način da vremenski
usklađuje različite fiziološke procese. Zaslužan je za ritmičnu ekspresiju gena, normalno
funkcioniranje imunosnog sustava, ritmičnu kontrolu krvnog tlaka, održavanje razina glukoze u
krvi, ali i za brojne druge funkcije. Utvrđeno je postojanje utjecaja cirkadijalne ritmičnosti na
farmakokinetske procese apsorpcije, distribucije, metabolizma i eliminacije određenih lijekova.
Kronoterapija, odnosno primjena lijeka u optimalno vrijeme unutar 24 sata ima za cilj poboljšanje
sigurnosti i učinkovitosti liječenja te postizanje boljih kliničkih ishoda liječenja.

Abstract (english)

In this dissertation, the influence of the circadian rhythm on the pharmacokinetic characteristics of
drugs are described, as well as the connection between circadian rhythm abnormalities and the
development of chronic diseases such as hypertension, asthma and diabetes.The circadian rhythm
has been developed in most living organisms in response to recurring daily changes in environmental
factors. The central regulatory "clock" consists of the suprachiasmatic nucleus in the hypothalamus,
while the peripheral "clocks" are located in the cells of peripheral tissues and communicate with
each other via nerve and humoral signals. The circadian rhythm helps to maintain the homeostasis
of the organism by synchronizing various physiological processes. It is responsible for the rhythmic
expression of genes, the normal functioning of the immune system, the rhythmic control of blood
pressure, the maintenance of blood glucose levels and for numerous other functions. The influence
of circadian rhythmicity on the pharmacokinetic processes of absorption, distribution, metabolism
and elimination of certain drugs has been established. Chronotherapy (application of the drug at the
optimal time within 24 hours) aims to improve the safety and effectiveness of the treatment and
achieve better clinical outcomes of the treatment.

• Keywords: cirkadijalni ritam; kronoterapija; dijabetes; astma; hipertenzija; središnji sat; periferni satovi; kronične bolesti
• Keywords (english): circadian rhythm; chronotherapy; diabetes; asthma; hypertension; central clock; peripheral clocks; chronic diseases
• Language: croatian
• URN:NBN: urn:nbn:hr:163:008285
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-04-02 11:21:53