Topikalna primjena ružmarina (Salvia rosmarinus Spenn.)

master's thesis

• Title (english): Topical appliacation of rosemary (Salvia rosmarinus Spenn.)
• Author: Paula Dorić
• Mentor: Ana-Marija Domijan (mentor)
• Committee member: Ana-Marija Domijan (predsjednik povjerenstva)
• Committee member: Dubravka Vitali Čepo (član povjerenstva)
• Committee member: Lovorka Vujić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical botany); Zagreb
• Defense date and country: 2024-04-19, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Problemi s kožom vrlo su česti te zahvaćaju ljude svih dobnih skupina. Stavljaju velik psihološki teret na pojedince i smanjuju kvalitetu života, a bolesti kože predstavljaju velik ekonomski teret za liječenje i prevenciju. Topikalna primjena lijekova najbolji je izbor za tretiranje ovakvih simptoma zbog svog brzog nastupa djelovanja te smanjenja mogućnosti sistemskih nuspojava, a biljni pripravci postaju sve popularniji izbor pacijenata prilikom liječenja benignijih stanja. Cilj ovog diplomskog rada bio je pregledati dostupnu literaturu o topikalnoj primjeni i učincima ružmarina (Salvia rosmarinus Spenn.) te utvrditi klinički značaj tih učinaka na kožne bolesti te potencijal uporabe u kozmetičkim pripravcima. Ružmarin je biljka s područja Mediterana, bogat je polifenolnim sastavnicama i triterpenima, a eterično ulje bogato mu je oksigeniranim monoterpenima. Poznat je po svojem antioksidativnom, antimikrobnom i protuupalnom djelovanju. Ovi učinci imaju velik potencijal u liječenju i prevenciji kožnih bolesti i stanja posebice nakon topikalne primjene pripravaka. U dostupnoj literaturi najviše se ističu studije koje su ispitivale učinak na alopeciju, upalne bolesti kože, dermatitise, uključujući i atopijski dermatitis, cijeljenje rana i starenje kože. Iako je provedeno čak i nekoliko kliničkih istraživanja koji potvrđuju dobar učinak pripravaka ružmarina u ovim indikacijama, daljnja opsežna istraživanja su potrebna kako bi se dodatno razjasnili mehanizmi djelovanja i sastavnice odgovorne za učinke.

Abstract (english)

Dermal problems are very common, and they affect people of all ages. They place a great psychological burden on the individual and reduce the quality of life, and skin diseases represent a great economic burden for treatment and prevention. Topical application of drugs is the best choice for the treatment of such symptoms due to its rapid onset of action and reduction of the possibility of systemic side effects, and herbal preparations are becoming an increasingly popular choice for patients when treating more benign conditions. The aim of this work was to review the literature on the topical application and effects of the rosemary (Salvia rosmarinus Spenn.) and determine the clinical significance of these effects on skin diseases and the potential for use in cosmetic preparations. Rosemary is a plant from the Mediterranean area, it is rich in polyphenolic components and triterpenes, and its essential oil is rich in oxygenated monoterpenes. It is known for its antioxidant, antimicrobial and anti-inflammatory effects. These effects have great potential in the treatment and prevention of skin diseases and conditions, especially after topical application of the preparations. In the available literature, the most prominent are studies that examined the effect on alopecia, inflammatory skin diseases, dermatitis, including atopic dermatitis, wound healing and skin aging. Although even a few clinical studies have been conducted that confirm positive effect of rosemary in these indications, further extensive research is needed to additionally clarify the mechanisms of action and the compounds responsible for the effects.

• Keywords: ružmarin; topikalna primjena; upala; cijeljenje rana; starenje kože
• Keywords (english): rosemary; topical application; inflammation; wound healing; skin aging
• Language: croatian
• URN:NBN: urn:nbn:hr:163:150255
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-05-23 13:27:06