Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima

master's thesis

• Title (english): Novel pharmacotherapy possibilities for treatment of infections caused by ESKAPE pathogens
• Author: Lucija Jagodić
• Mentor: Petra Turčić (mentor)
• Committee member: Petra Turčić (predsjednik povjerenstva)
• Committee member: Maja Ortner Hadžiabdić (član povjerenstva)
• Committee member: Ivana Perković (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology); Zagreb
• Defense date and country: 2024-03-19, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Antibiotici su nam godinama služili kao dragocjeno oružje u borbi s bakterijskim infekcijama i u
današnje doba teško je zamisliti život bez njih. Visoka učestalost višestrukorezistentnih sojeva
bakterija, s naglaskom na patogene okrunjene akronimom ESKAPE, i otežan razvoj novih
antibiotika značajno ograničavaju mogućnosti u terapiji bakterijskih infekcija i često dovode do
nepovoljnih kliničkih ishoda. Osim zbog neadekvatne mogućnosti osiguranja zdravlja različitih
skupina pacijenata, ove su infekcije i financijski teret za zdravstvo. Problem je prisutan na globalnoj
razini i nužno je što brže djelovanje u razvoju lijekova s drukčijim mehanizmima djelovanja. Pojava
višestrukorezistentnih sojeva predstavlja veliku opasnost u zdravstvenom sustavu, što se posebice
odnosi na pacijente već narušenog zdravlja koji ovakve infekcije najčešće steknu boravkom u
ustanovama povezanim sa zdravstvenom skrbi. Kako bismo si osigurali dovoljno vremena za
istraživanje novih terapijskih opcija za sprječavanje i liječenje bakterijskih infekcija, moramo se
fokusirati na očuvanje učinkovitosti postojećih antibiotika. Iako mnoge alternative antibioticima
pokazuju potencijal u rješavanju gorućeg problema antimikrobne rezistencije, u ovom trenutku i
dalje nemamo ništa konkretno, stoga nam ne preostaje ništa osim ulagati više napora u bazična i
klinička istraživanja

Abstract (english)

For decades antibiotics have served as a valuable weapon in the fight against bacterial infections
which is why it is impossible to imagine a world without them. However, increasing incidence of
MDR strains, especially pathogens summarised by acronym ESKAPE, along with challenges in
development of new antibiotics, all contribute to significant limitations in antimicrobial therapies
which often result in unwanted clinical outcomes. Besides inadequate care for various groups of
patients, these infections act as a financial burden to healthcare systems. The problem is present
across the globe and it is important to act quicker when it comes to development of new drugs with
different acting mechanisms. The MDR phenomenon presents a serious threat to healthcare systems,
which is particularly important for patients with pre-existing comorbidity who are usually the most
prone to these types of pathogens by residing in various health care facilities. Although alternatives
to antibiotics demonstrate some potential in resolving antimicrobial resistance, we do not have a
conclusive solution which is why it is important to invest more effort into basic and clinical trials.

• Keywords: ESKAPE patogeni; MDR; antimikrobna rezistencija
• Keywords (english): ESKAPE pathogens; MDR; antimicrobial resistance
• Language: croatian
• URN:NBN: urn:nbn:hr:163:646536
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-05-23 14:06:05