Metabolizam lijekova za liječenje kardiovaskularnih bolesti

master's thesis

• Title (english): Metabolism of drugs for the treatment of cardiovascular diseases
• Author: Anamaria Medak
• Mentor: Monika Barbarić (mentor)
• Committee member: Monika Barbarić (predsjednik povjerenstva)
• Committee member: Lidija Bach-Rojecky (član povjerenstva)
• Committee member: Ana Karković Marković (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry); Zagreb
• Defense date and country: 2024-06-26, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Kardiovaskularne bolesti su vodeći uzrok mortaliteta, a lijekovi koji se koriste u terapiji pripadaju najkorištenijim lijekovima na svijetu. Imaju ključnu ulogu u kontroli simptoma, liječenju, usporavanju progresije bolesti, kao i smanjenju rizika od ozbiljnih komplikacija. Lijekove možemo podijeliti u nekoliko kategorija prema ciljevima terapije i mehanizmu djelovanja: antihipertenzivi (inhibitori angiotenzin konvertirajućeg enzima (ACEi), blokatori receptora angiotenzina II (ARB), blokatori adrenergičkih receptora, blokatori kalcijevih kanala, antitrombotici (antikoagulansi, inhibitori agregacije trombocita), antiaritmici, hipolipemici i diuretici. Cilj diplomskog rada bio je prikazati metabolizam navedenih skupina lijekova koji se koriste u terapiji kardiovaskularnih bolesti s naglaskom na reakcije biotransformacije, svojstva metabolita i enzime uključene u biotransformaciju. Navedeni su i čimbenici koji mogu utjecati na varijabilnost u odgovoru na terapiju poput genetskih polimorfizama enzima i interakcija lijek-lijek.
Rezultati pregleda literature naglašavaju važnost razumijevanja metabolizma lijekova i individualizirani pristup terapiji u skladu s postojećim komorbiditetima i specifičnostima pacijenta.

Abstract (english)

Cardiovascular diseases are the leading cause of mortality, and the medications used in their therapy are among the most widely used drugs in the world. They play a crucial role in controlling symptoms, treating the disease, slowing its progression, and reducing the risk of serious complications. These medications can be categorized into several groups based on therapeutic goals and mechanisms of action: antihypertensives (angiotensin-converting enzyme inhibitors (ACE inhibitors), angiotensin II receptor blockers (ARBs), adrenergic receptor blockers, calcium channel blockers), antithrombotics (anticoagulants, platelet aggregation inhibitors), antiarrhythmics, hypolipidemics, and diuretics. The aim of this thesis was to present the metabolism of these groups of drugs used in the treatment of cardiovascular diseases, with a focus on biotransformation reactions, properties of metabolites, and enzymes involved in biotransformation. Factors that may influence variability in therapeutic response, such as genetic polymorphisms of enzymes and drug-drug interactions, were also described. The literature review results emphasize the importance of understanding drug metabolism and the individualized approach to therapy in accordance with existing comorbidities and patient-specific characteristics.

• Keywords: metabolizam; metaboliti; farmakokinetika; metabolizirajući enzimi; interakcije; kardiovaskularne bolesti
• Keywords (english): metabolism; metabolites; pharmacokinetics; metabolizing enzymes; interactions; cardiovascular diseases
• Language: croatian
• URN:NBN: urn:nbn:hr:163:915645
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-09-20 11:58:01