Farmakoterapijski pristup liječenju sindroma iritabilnog crijeva

master's thesis

• Title (english): Pharmacotherapeutic approach to the treatment of irritable bowel syndrome
• Author: Petra Raguž
• Mentor: Petra Turčić (mentor)
• Committee member: Petra Turčić (predsjednik povjerenstva)
• Committee member: Lidija Bach-Rojecky (član povjerenstva)
• Committee member: Laura Nižić Nodilo (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology); Zagreb
• Defense date and country: 2024-06-05, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Sindrom iritabilnog crijeva je kompleksna gastrointestinalna bolest i najčešći funkcionalni poremećaj crijeva. Bolest se manifestira različitim simptomima uključujući promjenu u broju i obliku stolica, bolovima u trbuhu, nadutosti i ponekada simptomima izvan gastrointestinalnog sustava. Etiopatogeneza bolesti je multifaktorijalna i uključuje različite genetske, mikrobiološke, imunološke, hormonalne i psihološke čimbenike. Dijagnoza SIC-a se postavlja isključivanjem drugih organskih bolesti i praćenjem Rimskih kriterija IV. Upravljanje SIC-om uključuje različite terapijske pristupe, farmakološke i nefarmakološke. Farmakološki pristupi obuhvaćaju laksative, antidijaroike, spazmolitike, antidepresive i ponekad antibiotike. Nefarmakološki pristupi podrazumijevaju prilagodbu prehrambenih navika, korištenje određenih dodataka prehrani i probiotika, redovitu tjelovježbu i psihoterapiju. Važno je istaknuti individualizirani pristup liječenju koji je ključan kod SIC-a, jer se simptomi bolesti i odgovor na terapiju razlikuju između pacijenata. Potrebna su daljnja istraživanja kako bi se bolje razumjeli mehanizmi ove bolesti i razvili učinkovitiji terapijski pristupi i podigla kvaliteta života bolesnika koji pate od sindroma iritabilnog crijeva.

Abstract (english)

Irritable bowel syndrome (IBS) is a complex gastrointestinal disorder and the most common functional bowel disorder. The disease manifests with various symptoms including changes in bowel habits, abdominal pain, bloating, and sometimes extra-intestinal symptoms. The etiopathogenesis of the disease is multifactorial and includes various genetic, microbiological, immunological, hormonal, and psychological factors. The diagnosis of IBS is established by excluding other organic diseases and following the Rome IV criteria. Management of IBS involves various therapeutic approaches, both pharmacological and non-pharmacological. Pharmacological approaches include laxatives, anti-diarrheal agents, spasmolytics, antidepressants, and sometimes antibiotics. Non- pharmacological approaches include dietary modifications, the use of specific dietary supplements and probiotics, regular exercise, and psychotherapy. It is important to emphasize the individualized approach to treatment, which is crucial in IBS, as symptoms and response to therapy vary among patients. Further research is needed to better understand the mechanisms of this disease and to develop more effective therapeutic approaches to improve the quality of life of patients suffering from irritable bowel syndrome.

• Keywords: sindrom iritabilnog crijeva; farmakološko liječenje; nefarmakološke mjere
• Keywords (english): irritable bowel syndrome; pharmacological treatment; non-pharmacological measures
• Language: croatian
• URN:NBN: urn:nbn:hr:163:372645
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-09-23 13:37:03