Elektrokemijske metode za istovremeno određivanje amlodipina i drugih lijekova za terapiju hipertenzije i hiperlipidemije

master's thesis

• Title (english): Electrochemical methods for simultaneous determination of amlodipine and other drugs for treating hypertension and hyperlipidemia
• Author: Nikola Puhin
• Mentor: Biljana Nigović (mentor)
• Committee member: Biljana Nigović (predsjednik povjerenstva)
• Committee member: Željan Maleš (član povjerenstva)
• Committee member: Sandra Jurić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical analysis); Zagreb
• Defense date and country: 2024-07-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Hipertenzija je najučestalija kardiovaskularna bolest i broj oboljelih od nje raste iz dana u dan. Za liječenje
hipertenzije dostupan je velik broj lijekova različitih mehanizama djelovanja, koji se zbog prirode bolesti često
kombiniraju. Lijek često zastupljen u tim kombinacijama je amlodipin, blokator kalcijevih kanala s posebnim
značajkama koje ga razlikuju od njemu srodnih lijekova. U ovom preglednom diplomskom radu prikazane su
voltametrijske metode koje se mogu koristiti za analizu samog amlodipina kao i za istovremenu analizu njega i drugog
lijeka/lijekova (hidroklorotiazid, atorvastatin, rosuvastatin, valsartan, ramipril, amilorid, atenolol i drugi). Pritom su u
istraživanjima najčešče proučavane pravokutnovalna i diferencijalno pulsna voltametrija kao i stripping voltametrijske
metode. Elektrode koje su najšire primjenjivane su krute elektrode: grafitna, staklasta ugljikova elektroda, dijamantna
elektroda, čije su površine vrlo često bile modificirane različitim vrstama nanomaterijala kako bi se optimizirali
procesi oksidacije, a samim time i rezultati analize. Prikazana je međusobna usporedba dostupnih voltametrijskih
metoda kao i njihova usporedba s ostalim komparativnim metodama (npr. HPLC). Objašnjene su prednosti
voltametrijskih metoda u odnosu na one koje se također koriste za analizu antihipertenziva.

Abstract (english)

Hypertension is the most common cardiovascular disease and the number of patients being diagnosed with it is getting
bigger and bigger every day. Many drugs with different mechanisms of action are available for treating hypertension
and because of the nature of the illness they are usually prescribed as a combination therapy. Medication often seen in
combination with other molecules is amlodipine, a calcium channel blocker with special features that differ him from
other calcium channel blockers.In this thesis, voltammetric methods that can be used for analysis of amlodipine alone
and for simultaneous analysis of amlodipine and other drug/drugs ( hydrochlorothiazide, atorvastatin, rosuvastatin,
valsartan, ramipril, amiloride, atenolol and others ) are shown. The most widely used methods for that purpose are
differential pulse and square - wave voltammetry, as well as adsorptive stripping voltammetric methods. Electrodes
described in this thesis are mainly solid electrodes: carbon paste electrode, boron – doped diamond electrode, glassy
carbon electrode etc, which surfaces were often modified using different nanomaterials. These modifications helped
optimising oxidation processes occuring on surface of electrodes and with that ensured getting better results of
analysis.Also, described voltammetric methods were compared to eachother as well as to other analytical methods also
used for determination of antihypertensive drugs ( for example HPLC). Advantages of voltammetric methods are also
listed in this thesis.

• Keywords: amlodipin; voltametrija; elektrode; metode; simultana analiza; određivanje; hipertenzija
• Keywords (english): amlodipine; voltammetry; electrodes; methods; simultaneous analysis; determination; hypertension
• Language: croatian
• URN:NBN: urn:nbn:hr:163:809126
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-09-25 13:07:36