Adherencija pacijenata s astmom i KOPB-om prema inhalatornoj terapiji i čimbenici utjecaja

master's thesis

• Title (english): Adherence of patients with asthma and COPD to inhalation therapy and influencing factors
• Author: Lucija Rovis
• Mentor: Maja Ortner Hadžiabdić (mentor)
• Mentor: Slaven Falamić (mentor)
• Committee member: Maja Ortner Hadžiabdić (predsjednik povjerenstva)
• Committee member: Slaven Falamić (član povjerenstva)
• Committee member: Petra Turčić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Centre for applied pharmacy); Zagreb
• Defense date and country: 2024-07-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Kronične bolesti su stanja koja prate pacijente tijekom cijelog života i obično se ne mogu potpuno izliječiti. Kod
kroničnih respiratornih bolesti poput KOPB-a i astme, redovita primjena inhalatorne terapije izuzetno je važna kako bi
se smanjila učestalost akutnih pogoršanja i smanjilo opterećenje zdravstvenog sustava. Stoga, pridržavanje terapije jedan
je od ključnih faktora u liječenju kroničnih bolesti. U istraživanju su sudjelovali pacijenti koji boluju od astme ili KOPBa i koriste minimalno jedan inhalator u terapiji. Istraživanje je provedeno na području Slavonije i Dalmacije, a uključivalo
je 100 ispitanika. Veći broj ispitanika boluje od astme (71%), a najčešće korišten inhalator je MDI - inhalatori aerosola
(40%). Rezultati istraživanja pokazuju da je najveći broj pacijenata djelomično adherentan (37%), dok je najmanji broj
pacijenata adherentan (29%). Parametri koji su statistički značajno utjecali na razinu pridržavanja su zaposlenost
(p=0,001) i dob (p=0,016). Nezaposleni pacijenti i stariji pacijenti pokazali su veću razinu adherencije. Također,
istraživanje je otkrilo da većina pacijenata (99%) poznaje svoj terapijski režim, dok manji broj pacijenata (35%) čini
kritične pogreške prilikom inhalacije lijeka. Personalizirani pristupi liječenju, edukacija pacijenata i provjera inhalacijske
tehnike od strane farmaceuta ključni su za poboljšanje adherencije.

Abstract (english)

Chronic diseases are lifelong conditions that usually cannot be completely cured. In chronic respiratory diseases such as COPD and asthma, regular use of inhalation therapy is crucial to reduce the frequency of acute exacerbations and alleviate the burden on the healthcare system. Thus, adherence to therapy is a key factor in the treatment of chronic diseases. This study involved patients with asthma or COPD who use at least one inhaler in their therapy. Conducted in the regions of Slavonia and Dalmatia, the research included 100 participants. A larger proportion of participants had asthma (71%), and the most commonly used type of inhaler was the MDI aerosol inhaler (40%). The study results showed that the majority of patients were partially adherent (37%), while the smallest proportion could be considered fully adherent (29%). Employment status (p=0.001) and age (p=0.016) were the parameters that significantly influenced the level of adherence to inhalation therapy. Unemployed and older patients showed a higher level of adherence. Additionally, the study revealed that most patients (99%) knew their therapeutic regimen, while a smaller number of patients (35%) made critical errors during inhalation. Personalized treatment approaches, patient education, and pharmacist-led inhalation technique checks are crucial for improving adherence.

• Keywords: astma; kronična opstruktivna plućna bolest; KOPB; stupanj adherencije; inhalacijska tehnika
• Keywords (english): asthma; chronic obstructive pulmonary disease; COPD; level of adherence; inhalation technique
• Language: croatian
• URN:NBN: urn:nbn:hr:163:288691
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2025-07-11
• Created on: 2024-10-08 07:17:19