Lijekovi u liječenju hipersekrecije želučane kiseline

master's thesis

• Title (english): Medications in the treatment of gastric acid hypersecretion
• Author: Dora Petras
• Mentor: Lidija Bach-Rojecky (mentor)
• Committee member: Lidija Bach-Rojecky (predsjednik povjerenstva)
• Committee member: Maja Bival Štefan (član povjerenstva)
• Committee member: Laura Nižić Nodilo (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology); Zagreb
• Defense date and country: 2024-09-09, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Želučana kiselina ključna je za normalnu probavu i apsorpciju hranjivih tvar te ima važnu ulogu u zaštiti probavnog sustava od patogena. Međutim, hipersekrecija želučane kiseline može uzrokovati značajne zdravstvene probleme, uključujući gastroezofagealnu refluksnu bolest (GERB), peptički ulkus i Zollinger-Ellisonov sindrom. Ove bolesti imaju kronični tijek, praćene su neugodnim simptomima te značajno narušavaju kvalitetu života oboljelih.
Ovim preglednim radom prikazane su farmakološke karakteristike lijekova koji se koriste za kontrolu hipersekrecije želučane kiseline, uključujući antacide, antagoniste histaminskih H2-receptora i inhibitore protonske pumpe. Svaka od ovih skupina lijekova ima specifične mehanizme djelovanja, farmakokinetske posebnosti, prednosti i nedostake, koje je potrebno poznavati i razumjeti kako bi se za svakog pacijenta odabrao optimalni lijek. Inhibitori protonske pumpe su najučinkovitija terapija te se danas koriste kao glavna terapijska opcija kod poremećaja hiperaciditeta. Međutim, njihova dugotrajna primjena zahtijeva pažljivo praćenje zbog potencijalnih nuspojava, uključujući malapsorpciju vitamina i minerala, povećan rizik od prijeloma i infekcija.
Ključnu ulogu u ispravnoj primjeni lijekova imaju ljekarnici. Kao stručnjaci za lijekove, trebaju osigurati da pacijenti razumiju zašto koriste određene lijekove i kako ih pravilno primjenjivati. Edukacija pacijenata o pravilnoj upotrebi lijekova, mogućim interakcijama i nuspojavama može značajno doprinijeti uspjehu terapije i smanjenju rizika od neželjenih posljedica.

Abstract (english)

Gastric acid is crucial for normal digestion and absorption of nutrients and plays an important role in protecting the
digestive system from pathogens. However, hypersecretion of gastric acid can lead to significant health problems,
including gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. These conditions
have a chronic course, are accompanied by unpleasant symptoms, and significantly impair the quality of life of affected
individuals.
This review presents the pharmacological characteristics of drugs used to control gastric acid hypersecretion, including
antacids, histamine H2-receptor antagonists, and proton pump inhibitors. Each of these drug classes has specific
mechanisms of action, pharmacokinetic properties, advantages, and disadvantages that need to be understood to select
the optimal medication for each patient. Proton pump inhibitors are the most effective therapy and are currently used as
the main therapeutic option for hyperacidity disorders. However, their long-term use requires careful monitoring due to
potential side effects, including malabsorption of vitamins and minerals, increased risk of fractures, and infections.
Pharmacists play a key role in the correct application of these medications. As medication experts, they should ensure
that patients understand why they are using certain drugs and how to use them properly. Educating patients on the correct
use of medications, possible interactions, and side effects can significantly contribute to the success of therapy and
reduce the risk of adverse outcomes.

• Keywords: želučana kiselina; sekrecija želučane kiseline; gastroezofagealna refluksna bolest; peptički ulkus; antacidi; blokatori H2 receptora; inhibitori protonske pumpe
• Keywords (english): gastric acid; gastric acid secretion; gastroesophageal reflux disease; peptic ulcer; antacids; H2 receptor blockers; proton pump inhibitors
• Language: croatian
• URN:NBN: urn:nbn:hr:163:149868
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-10-10 10:55:30