Određivanje neesencijalnih elemenata u kapsuliranim dodacima prehrani za liječenje upalnih bolesti crijeva GFAAS tehnikom

master's thesis

• Title (english): Determination of non-essential elements in encapsulated dietary supplements for the treatment of inflammatory bowel diseases
• Author: Filip Filošević
• Mentor: Daniela Amidžić Klarić (mentor)
• Committee member: Daniela Amidžić Klarić (predsjednik povjerenstva)
• Committee member: Ana Mornar Turk (član povjerenstva)
• Committee member: Marijana Zovko Končić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical analysis); Zagreb
• Defense date and country: 2024-09-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Upalne bolesti crijeva pogađaju sve veći broj pacijenata diljem svijeta. U današnje vrijeme brojni
pacijentu se okreću samoliječenju i posežu za brojnim dodacima prehrani. Provode se brojna
istraživanja kojima se dokazuje njihova korisnost. Međutim, jako je važno zaštiti pacijente i osigurati
kvalitetu dodataka prehrani propisanu smjernicama. Jedan od zahtjeva smjernica je i količina
elementarnih onečišćenja koja mogu imati toksične učinke na ljudsko zdravlje. Stoga je cilj ovoga
diplomskog rada bio odrediti sadržaj srebra, kositra i barija u dodacima prehrani za liječenje upalnih
bolesti crijeva. Sadržaj navedenih neesencijalnih elemenata određen je metodom grafitne atomske
apsorpcijske spektrometrije. Srednja vrijednost koncentracije srebra i kositra niža je u mekim
kapsulama, dok se sadržaj barija u tvrdim i mekim kapsulama nije statistički značajno razlikovao.
Količine elementarnih onečišćenja srebra, kositra i barija odgovaraju zahtjevima aktualnih smjernica
ICH Q3 o najvećem dopuštenom dnevnom unosu elementarnog onečišćenja.

Abstract (english)

Inflammatory bowel diseases are affecting an increasing number of patients worldwide. Today, many
patients turn to self-medication and use various dietary supplements. Numerous studies are being
conducted to demonstrate their effectiveness. However, it is crucial to protect patients and ensure
the quality of dietary supplements as prescribed by the guidelines. One of the requirements of these
guidelines is the limitation of elemental impurities, which can have toxic effects on human health.
Therefore, this thesis aimed to determine the content of silver, tin and barium in dietary supplements
for the treatment of inflammatory bowel diseases. The content of the mentioned non-essential
elements was determined using the graphite furnace atomic absorption spectrometry method. The
average concentration of silver and tin is lower in soft capsules, while the barium content in hard
and soft capsules did not differ statistically significantly. The levels of silver, tin and barium
elemental impurities comply with the requirements of the current ICH Q3 guidelines regarding the
maximum permissible daily intake of elemental impurities.

• Keywords: elementarna onečišćenja; grafitna tehnika; dodaci prehrani; upalne bolesti crijeva; srebro; kositar; barij
• Keywords (english): elemental impurities; graphite furnace; dietary suplemments; inflammatory bowel diseases; silver; tin; barium
• Language: croatian
• URN:NBN: urn:nbn:hr:163:413699
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2026-09-10
• Created on: 2024-10-11 10:46:28