Hijaluronska kiselina i cijeljenje rana

postgraduate specialist thesis

• Author: Daria Pecotić
• Mentor: Jelena Filipović-Grčić (mentor)
• Committee member: Jelena Filipović-Grčić (predsjednik povjerenstva)
• Committee member: Anita Hafner (član povjerenstva)
• Committee member: Ines Sjerobabski Masnec (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2024-09-26, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj: Cilj ovog rada bio je sustavni pregled literature o ulozi hijaluronske kiseline (HA)
i njezinih obloga i terapijskih sustava u zacjeljivanju rana, s naglaskom na njezine
biološke funkcije, molekularne mehanizme djelovanja i potencijalne kliničke
primjene.
Metode: Provedena je sveobuhvatna analiza dostupne literature, uključujući
znanstvene članke, pregledne radove i kliničke studije koje se bave ulogom HA-e u
procesu zacjeljivanja rana. Poseban naglasak stavljen je na formulacije koje
uključuju HA-u te usporedba s drugim biopolimerima poput kitozana i alginata.
Rezultati: Rezultati pokazuju da HA igra ključnu ulogu u regulaciji upalnog
odgovora, stimulaciji angiogeneze i reorganizaciji ekstracelularnog matriksa, čime se
ubrzava proces zacjeljivanja rana. Komercijalni pripravci s HA-om pokazali su se
učinkovitim u različitim kliničkim studijama, dok kombinacija HA-e s drugim
biopolimerima nudi dodatne prednosti, uključujući dugotrajnu hidrataciju i poticanje
regeneracije tkiva.
Zaključak: Hijaluronska kiselina je središnja komponenta u modernim terapijskim
pristupima za liječenje rana. Njezina primjena u kombinaciji s drugim bioaktivnim
tvarima i naprednim tehnologijama, poput 3D bioprintanja, pruţa nove mogućnosti za
poboljšanje ishoda liječenja. Daljnja istraţivanja trebaju biti usmjerena na
optimizaciju formulacija i primjenu HA-e u personaliziranoj medicini.

Abstract (english)

Objective: The aim of this work was to provide a systematic review of the literature
on the role of hyaluronic acid (HA) and its dressings and delivery systems in wound
healing, with a focus on its biological functions, molecular mechanisms of action, and
potential clinical applications.
Methods: A comprehensive analysis of the available literature was conducted,
including scientific articles, review papers, and clinical studies that address the role
of HA in the wound healing process. Special emphasis was placed on formulations
containing HA and comparisons with other biopolymers such as chitosan and
alginate.
Results: The results indicate that HA plays a crucial role in regulating inflammatory
response, stimulating angiogenesis, and reorganizing the extracellular matrix,
thereby accelerating the wound healing process. Commercial HA-based
preparations have proven effective in various clinical studies, while the combination
of HA with other biopolymers offers additional benefits, including sustained hydration
and enhanced tissue regeneration.
Conclusion: Hyaluronic acid is a central component in modern therapeutic
approaches for wound treatment. Its application in combination with other bioactive
substances and advanced technologies, such as 3D bioprinting, provides new
opportunities for improving treatment outcomes. Further research should focus on
optimizing formulations and applying HA in personalized medicine.

• Keywords: hijaluronska kiselina; zacjeljivanje rana; biopolimeri; terapijski sustavi; komercijalni pripravci
• Keywords (english): hyaluronic acid; wound healing; biopolymers; drug delivery systems; commercial preparations
• Language: croatian
• URN:NBN: urn:nbn:hr:163:565172
• Study programme: Title: Dermatopharmacy and cosmetology - specialistic - university; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni specijalist dermatofarmacije i kozmetologije (sveučilišni specijalist dermatofarmacije i kozmetologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2025-03-28 12:50:47