Nanotehnološki nosači biljnih tvari i pripravaka

master's thesis

• Title (english): Nanotechnological carriers of herbal preparations and substances
• Author: Ana Škrbina
• Mentor: Ivan Pepić (mentor)
• Committee member: Ivan Pepić (predsjednik povjerenstva)
• Committee member: Jasmina Lovrić (član povjerenstva)
• Committee member: Marijana Zovko Končić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2016-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Biljne tvari naročito su važne u kliničkoj primjeni zbog djelovanja na više signalnih bioloških
putova i opsežnom mijenom genske ekspresije te posljedičnim širokim spektrom djelovanja,
prikladnijim za liječenje multifaktorijalnih bolesti. Međutim, fizikalno-kemijska svojstva
takvih tvari često ograničavaju njihovu farmaceutsku upotrebu. Molekule biološkog podrijetla
često su nestabilne, praktično netopljive u vodi, zanemarive biodostupnosti ili imaju veliku
molekularnu veličinu, zbog čega ne mogu prolaziti lipidne biološke barijere i stoga pokazuju
lošu apsorpciju.
Uklapanjem biljnih tvari u nanonosače moguće je poboljšati njihovu topljivost i
biodostupnost, povećati stabilnost, smanjiti toksičnost te poboljšati biološku aktivnost.
Nadalje, nanotehnološki nosači omogućuju kontinuirano i kontrolirano oslobađanje biljne
tvari, duboku penetraciju u tkivo te unos biljne tvari u stanice. Prilagodbom fizikalnokemijskih
svojstava nanoterapeutika postiže se pasivno ili aktivno usmjeravanje djelovanja
djelatne tvari i upravlja se profilom njezinog oslobađanja, što bi potencijalno moglo pomoći u
terapiji i prevenciji kroničnih bolesti.
Unatoč brojnim pozitivnim rezultatima pretkliničkih ispitivanja različitih nanotehnoloških
oblika, njihovu djelotvornost i sigurnost primjene potrebno je potvrditi budućim kliničkim
ispitivanjima.

Abstract (english)

Natural products are especially important in clinical use due to their effect on various
biological signal pathwys and due to their ability to change gene expression and act in broad
spectrum, which makes them suitable for treatment of multifactorial diseases. Unfortunately,
phisicochemical attributes of natural molecules often limit their pharmaceutical use. These
products are usually unstable, insoluble in water, have very low bioavailability or have big
molecular size, which prevents them from crossing lipid biological barriers and lowers the
absorption.
Incapsulation of active molecules in nanotechnological carriers improves their solubility,
bioavailability and stability, decreases toxicity and can increase biological activity.
Additionally, nanotechnological carriers enable sustained and controlled release of active
molecule, deep tissue penetration and intracellular delivery. By modifying phisicochemical
properties of nanotherapeutics it is possible to achieve passive or active targeting and to
control drug release patterns, which could help fighting chronical diseases.
Altough many successful preclinical trials of various nanotechnological carriers have been
conducted, it is still necessary to affirm their effectivness, safety and nontoxicity in clinical
trials and in practical use.

• Keywords: nanotehnološki nosači; liposomi; niosomi; nanoemulzije; nanočestice; nanokristali; biljni pripravci
• Keywords (english): nanotechnological carriers; liposomes; niosomes; nanoemulsions; nanoparticles; nanocrystals; herbal preparations
• Language: croatian
• URN:NBN: urn:nbn:hr:163:032560
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-11-18 15:06:26