Terapijski potencijal kanabinoida u neurološkim oboljenjima

master's thesis

• Title (english): The therapeutic potential of cannabinoids in neurological diseases
• Author: Marija Mišković
• Mentor: Sanda Vladimir-Knežević (mentor)
• Committee member: Sanda Vladimir-Knežević (predsjednik povjerenstva)
• Committee member: Biljana Blažeković (član povjerenstva)
• Committee member: Željka Vanić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2016-09-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Konoplja (Cannabis sativa L., Cannabinacae) je biljka koja se tisućama godina koristi u ljekovite svrhe. Dosadašnja istraživanja identificirala su nekoliko stotina bioaktivnih sastavnica, među kojima se ističu kanabinoidi. Aktivacijom CB1 i CB2 kanabinoidnih receptora kanabinoidi ostvaruju brojne učinke. U ovom radu pozornost je usmjerena na njihovo djelovanje u središnjem živčanom sustavu gdje regulacijom sinaptičke transmisije pomažu u olakšavanju teških simptoma u pacijenata oboljelih od MS i epilepsije. Iako su dosadašnji eksperimentalni podaci o terapijskom potencijalu kanabinoida u drugim neurološkim oboljenjima pozitivni, potrebna su daljnja klinička istraživanja.

Abstract (english)

Cannabis (Cannabis sativa L., Cannabinacae) is a plant used thousands of years for medicinal purposes. Previous studies have identified hundreds of bioactive components, including prominent cannabinoids. By activating CB1 and CB2 cannabinoid receptors, cannabinoids generate numerous effects. In this work the focus is on their activity in the central nervous system where regulation of synaptic transmission helps relieve severe symptoms in patients suffering from MS and epilepsy. Although the current experimental data on the therapeutic potential of cannabinoids in other neurological disorders are positive, further clinical trials are needed.

• Keywords: Cannabis sativa; medicinska konoplja; multipla skleroza; epilepsija; neurološka oboljenja
• Keywords (english): Cannabis sativa; medical cannabis; multiple sclerosis; epilepsy; neurological diseases
• Language: croatian
• URN:NBN: urn:nbn:hr:163:670823
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-11-25 09:26:15