Title | Predviđanje farmakokinetike i toksičnosti statina primjenom programskih paketa PreADMET i pkCSM |
Author | Katarina Božić |
Mentor(s) | Ana Mornar Turk (thesis advisor)
|
Abstract | U istraživanju potencijalnih lijekova dugo vremena srž istraživanja predstavljala je potragu za
novom molekulom s ciljanom farmakološkom aktivnosti. Danas je poznato kako najprikladniji
lijek nije nužno onaj s najznačajnijom aktivnosti, već upravo lijek kod kojeg je odnos između
učinkovitosti, sigurnosti, farmakokinetike, interakcije s drugim lijekovima te troškova proizvodnje
najprikladniji. Stoga se farmakokinetika lijeka ispituje već u najranijim fazama njegova
istraživanja.
In silico ispitivanje farmakokinetike lijekova od iznimnog je značaja u najranijim fazama
istraživanja budući da omogućava predviđanje farmakokinetike potencijalnog, još nesintetiziranog
lijeka. Čitav niz on-line kao i komercijalno dostupnih programa omogućava uvid u
farmakokinetičko ponašanje potencijalnog lijeka već unutar nekolikom minuta. No, kako bi se
dobili pozdani podaci potrebno je redovito evaluirati njihovu primjenu.
Cilj ovog rada bio je ispitati farmakokinetička svojstva lijekova iz skupine statina primjenom dva
nova programska paketa: PreADMET i pkCSM.
Provedenim istraživanjem uočeno je kako se neki od ispitanih parametra značajno razlikuju ovisno
o korištenom računalnom programskom paketu. Stoga je moguće zaključiti kako daljnja
istraživanja trebaju biti usmjerena na evaluacija ovih programskih paketa u smislu usporedbe
eksperimentalno dobivenih podataka s teorijskim vrijednostima. |
Keywords | statins pharmacokinetics toxicity in silico PreADMET pkCSM |
Parallel title (English) | Prediction of pharmacokinetics and toxicity of statins using software package PreADMET and pkCSM |
Committee Members | Ana Mornar Turk (committee chairperson) Biljana Nigović (committee member) Maja Šegvić Klarić (committee member)
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Granter | University of Zagreb Faculty of Pharmacy and Biochemistry |
Lower level organizational units | Department of pharmaceutical analysis |
Place | Zagreb |
State | Croatia |
Scientific field, discipline, subdiscipline | BIOMEDICINE AND HEALTHCARE Pharmacy Pharmacy
|
Study programme type | university |
Study level | integrated undergraduate and graduate |
Study programme | Pharmacy |
Academic title abbreviation | mag. pharm. |
Genre | master's thesis |
Language | Croatian |
Defense date | 2016-09-29 |
Parallel abstract (English) | For a long time the core of the research of potential drugs was the search for a new molecule with
a target pharmacological activity. Today it is known that the most appropriate drug is not
necessarily the one with the most significant activities, then the drug in which the relationship
between the efficiency, safety, pharmacokinetics, interactions with other drugs and the cost of
producing the most suitable. Therefore, the pharmacokinetics of the drug tests in the earliest stages
of research.
In silico study of drugs pharmacokintics is of utmost importance in the earliest stages of research
as it allows the prediction of pharmacokinetics of potential, still unsynthetized drug. A whole
range of on-line as well as commercially available software provides insight into the
pharmacokinetic behaviour of potential drug within a few minutes. But in order to get a reliable
data it is necessary to regularly evaluate their application. The aim of this study was to investigate
the pharmacokinetic properties of drugs from the group of statins using two new software
packages: PreADMET and pkCSM.
Conducted research it was observed that some of the examined parameters vary significantly
depending on the software package. It is possible to conclude that further research should be
focused on the evaluation of these software packages in terms of comparing the experimental data
with the theoretical values. |
Parallel keywords (Croatian) | statini farmakokinetika toksičnost in silico PreADMET pkCSM |
Resource type | text |
Access condition | Access restricted to students and staff of home institution |
Terms of use |  |
URN:NBN | https://urn.nsk.hr/urn:nbn:hr:163:901240 |
Committer | Petra Gašparac |