Autologni serumi u obliku kapi za oko

master's thesis

• Title (english): Autologous serum eye drops
• Author: Marina Pranjić
• Mentor: Ivan Pepić (mentor)
• Committee member: Ivan Pepić (predsjednik povjerenstva)
• Committee member: Anita Hafner (član povjerenstva)
• Committee member: Iva Mucalo (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2016-09-30, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Autologni serumi u obliku kapi za oko se sve više koriste za liječenje sindroma suhog oka i drugih
nedostataka epitela rožnice, a obično se propisuju nakon što se ne postignu očekivani ishodi
konvecionalnim liječenjem. Autologni serumi u obliku kapi za oko izrađuju se iz pacijentove krvi
preko autologne kolekcije. Faktori rasta, vitamini A i E, fibronektin i albumini sadržani u takvim
kapima za oko smatraju se najvažnijim za proliferaciju epitelnih stanica rožnice koja je često
smanjena. Zbog ograničenog broja kliničkih ispitivanja i malog broja pacijenata koji su koristili
takve kapi za oko, potrebno je provesti daljnja klinička ispitivanja kojima bi se potvrdila
djelotvornost i sigurnost primjene autolognih seruma u obliku kapi za oko.

Abstract (english)

Serum eye drops are being used increasingly to treat dry eye syndrome and persistent corneal
epithelial defects, and are usually prescribed when conventional treatments fail. Serum eye drops
are commonly sourced from the patient’s own blood via an autologous collection. Serum contains
growth factors and vitamins such as epithelial growth factor, platelet derived growth factor,
vitamin A and E, fibronectin, and albumin, which are required for corneal epithelial proliferation
and repair and often reduced in dry eye syndrome. Further randomised controlled trials are needed,
in order to assess the safety and efficacy of the serum eye drops.

• Keywords: Autologni serum; suho oko; kapi za oko; suze
• Keywords (english): autologous serum; dry eye; eye drop; tears
• Language: croatian
• URN:NBN: urn:nbn:hr:163:081480
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2016-12-06 14:05:24