The paraoxonase 1, 2 and 3 in humans

Scientific paper - Review paper

• Author: Marija Grdic Rajkovic
• Author: Lada Rumora
• Author: Karmela Barisic
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medical biochemistry and haematology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Medical Biochemistry

Abstract (english)

The paraoxonase gene family in humans includes three members: PON1, PON2 and PON3. The pro-ducts of those three genes are the following enzymes: paraoxonase 1 (PON1), paraoxonase 2 (PON2) and paraoxonase 3 (PON3). PON1 is mainly associated with a high density lipoprotein (HDL). A small amount of this enzyme is also bound to very low-density lipoprotein (VLDL) and postprandial chylomicrons. PON1 possess organophosphatase, arylesterase and lactonase activity and it hydrolyzes many different substrates. It is also known that PON1 may have antiatherogenic function. Compared to the PON1, PON2 and PON3 are much less studied and described. PON2 is ubiquitously expressed intracellular protein, while PON3 is bound to HDL, like PON1. The both enzymes possess antioxidant properties.

• Keywords (english): paraoxonase 1; paraoxonase 2; paraoxonase 3
• Language: english
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Biochemia Medica
• Numbering: vol. 21, no. 2, pp. 122-130
• p-ISSN: 1330-0962
• e-ISSN: 1846-7482
• URN:NBN: urn:nbn:hr:163:274640
• Publication: 2011-06-15
• Document URL: http://hrcak.srce.hr/69654
• Type of resource: Text
• Access conditions: Open access
• Created on: 2017-06-14 15:13:12