Utjecaj koncentracije hidroksietilceluloze na reološka svojstva i oslobađanje mupirocin-kalcija iz topikalnih emulzija

master's thesis

• Title (english): The impact of the amount of hydroxyethylcellulose on the rheological properties and the release of mupirocin-calcium from topical emulsions
• Author: Dina Ivankov
• Mentor: Biserka Cetina Čižmek (mentor)
• Committee member: Biserka Cetina Čižmek
• Committee member: Jasmina Lovrić
• Committee member: Jelena Filipović-Grčić
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; hr
• Defense date and country: 2015-07-07, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

U ovom istraživanju pripremljene su i uspoređene tri formulacije mupirocinske kreme tipa U/V emulzije različitog udjela hidroksietilceluloze HHX. Usporedba se temelji na njihovim reološkim karakteristikama i brzini oslobađanja mupirocina iz formulacija. Reološkim ispitivanjima provedenim pomoću reometra Physica MCR 301su dobiveni profili viskoznosti i viskoelastičnosti. Profili oslobađanja mupirocina iz krema su izmjereni pomoću Franz-difuzijskih ćelija i HPLC uređaja. Kod krema s većim udjelom hidroksietilceluloze HHX viskoznost je veća i kod sve tri formulacije ona opada povećanjem brzine smicanja, što govori da je sustav pseudoplastičan. Sve tri formulacije kreme imaju veću vrijednost modula elastičnosti od vrijednosti modula viskoznosti. S porastom naprezanja modul elastičnosti se smanjuje brže od modula viskoznosti. Kreme s manjim udjelom hidroksietilceluloze HHX, tj. one manje viskozne, imaju nižu graničnu vrijednost tečenja. Kada se stave u odnos oslobođena količina mupirocina prema drugom korijenu vremena, dobije se linearna ovisnost. Iz toga zaključujemo da se oslobađanje lijeka iz polukrutih formulacija može opisati Higuchijevim modelom. Lijek se brže oslobađa iz manje viskoznih formulacija.

Abstract (english)

In this study three formulations of mupirocin U/V creams with different amount of hydroxyethylcellulose HHX are prepared and compared. Comparison is based on their rheological characteristics and release rate of mupirocin. Viscosity and viscoelasticity profiles were measured using a rheometer Physica MCR 301. Release profiles were obtained using Franz-diffusion cells and HPLC equipment. Viscosity of creams increases with higher amount of hydroxyethylcellulose HHX and decreases with increasing shear rate indicating pseudoplastic behavior. All three cream formulations have higher value of elastic modulus than the viscous modulus. With increasing shear stress elastic modulus decreases faster than viscous modulus. Creams with lower amount of hydroxyethylcellulose HHX, which are less viscous, have also lower limiting value of the linear viscoelastic range. By setting the relationship between the amount of released mupirocin to the square root of the time a linear dependence was obtained. Therefore, it can be concluded that the drug release from the investigated semi-solid formulations can be described by the Higuchi diffusion model. The drug release was faster from the formulations of lower viscosity.

• Keywords: hidroksietilceluloza; mupirocin-kalcij; reološka svojstva; oslobađanje aktivne supstancije
• Keywords (english): hydroxyethylcellulose; mupirocin-calcium; rheology; drug release
• Language: croatian
• URN:NBN: urn:nbn:hr:163:355057
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2016-01-19 16:16:59