Quantitative modeling of flavonoid glycosides isolated from Paliurus spina-christi Mill.

Scientific paper - Original scientific paper

• Author: Marica Medić-Šarić
• Author: Željan Maleš
• Author: Slavko Šarić
• Author: Adelheid Brantner
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Several QSPR models for predicting the properties of flavonoid glycosides isolated from Paliurus spina-christi Mill, and of some related flavonoids were described and evaluated. Log P values for all of them were calculated according to the method of Rekker. All investigated flavonoids showed expressive hydrophobicity. Significant correlation between the partition coefficient, log P, and van der Waals volume, Vw (calculated according to the method described by Moriguchi et al.) was obtained. Topological indices used for correlation analysis include the Wiener index, W(G), valence connectivity index, £V(G), Balaban index, J{G), and information-theoretic index, 7(G). The best models were obtained with the valence connectivity index for all the flavonoids studied.

• Keywords (croatian): flavonoid glycosides; Paliurus spina-christi Mill.
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Croatica Chemica Acta
• Numbering: vol. 69, no. 4, pp. 1603-1616
• p-ISSN: 0011-1643
• e-ISSN: 1334-417X
• URN:NBN: urn:nbn:hr:163:036951
• Publication: 1996-12-02
• Document URL: https://hrcak.srce.hr/135994
• Type of resource: Text
• Access conditions: Open access
• Created on: 2018-01-31 14:43:06