Antimicrobial activity of some hydroxamic acids

Scientific paper - Original scientific paper

• Title (croatian): Antimikrobni učinak nekih hidroksamskih kiselina
• Author: Stjepan Pepeljnjak
• Author: Branka Zorc
• Author: Ivan Butula; MBZ: 6372
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of microbiology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Several hydroxamic acids, viz., N-benzyl-N'-hydroxysuccinamide (BHS) (1), poly[alpha,beta-(N-hydroxy)-DL-aspartamide] (PHA) (2), poly[alpha,beta-(N-hydroxy-N-methyl-DL-aspartamide)] (PMHA) (3) and poly [alpha,beta-(N-hydroxy)-DL-aspartamide]/poly[alpha,beta-(N-2-hydroxyethyl)-DL-aspartamide] (PHA-PHEA 1:1) (4) were prepared and screened for their antimicrobial activity. Ten Gram-positive and 7 Gram-negative species of bacteria, 5 Candida species, 4 dermatophytes species and 3 mould species were used in tests. Compound 1 showed no antimicrobial activity on any of the tested microorganisms. Other compounds (2-4) showed a narrow spectrum of antibacterial activity, but no antifungal activity.

Abstract (croatian)

U radu je ispitano antimikrobno djelovanje nekoliko hidroksamskih kiselina: N-benzil-N’-hidroksi-sukcinamida (BHS) (1), poli[alpha,beta-(N-hidroksi)-DL-aspartamida](PHA) (2),
poli[alpha,beta-(N-hidroksi-N-metil-DL-aspartamida)](PMHA) (3) i poli[alpha,beta-(N-hidroksi)-DL-aspartamid]/poli[alpha,beta-(N-2- -hidroksietil)-DL-aspartamid] kopolimera (PHA-PHEA) (4). Antimikrobno djelovanje ispitano je na 10 Gram-pozitivnih i 7 Gram-negativnih bakterija, 5 vrsta kandida, 4 vrste dermatofita i 3 vrste plijesni. Supstancija 1 ne pokazuje antimikrobno djelovanje na ispitivane vrsta bakterija i gljivica. Ostali spojevi (2–4) imaju relativno slabo antimikrobno djelovanje na Gram-pozitivne i Gram-negativne bakterije i ne pokazuju antifungalni učinak.

• Keywords (english): hydroxamic acid; polyhydroxamic acid; antimicrobial activity
• Keywords (croatian): hidroksamska kiselina; polihidroksamska kiselina; antimikrobno djelovanje
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Acta Pharmaceutica
• Numbering: vol. 55, no. 4, pp. 401-408
• p-ISSN: 1330-0075
• e-ISSN: 1846-9558
• URN:NBN: urn:nbn:hr:163:343095
• Publication: 2005-12-01
• Document URL: https://hrcak.srce.hr/19045
• Type of resource: Text
• Access conditions: Open access
• Created on: 2018-02-14 13:43:47