The novel ketoprofenamides: synthesis and spectroscopic characterization

Scientific paper - Original scientific paper

• Author: Marijana Zovko
• Author: Branka Zorc
• Author: Milena Jadrijević-Mladar Takač
• Author: Biserka Metelko
• Author: Predrag Novak
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Synthesis of a series of new ketoprofenamides (3a-h) is described. Amide formation was achieved by aminolysis of ketoprofen benzotriazolide (2) with various amines: primary, secondary, hydroxylamine and amino acid β-alanine. The structures of synthesized compounds were characterized by means of IR, 1H and 13C NMR spectroscopies and elemental analysis. The synthesized compounds are potential prodrugs of a well-known NSAID ketoprofen.

• Keywords (english): ketoprofen; amide; benzotriazole; synthesis; FTIR and NMR spectroscopy
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Croatica Chemica Acta
• Numbering: vol. 76, no. 4, pp. 335-341
• p-ISSN: 0011-1643
• e-ISSN: 1334-417X
• URN:NBN: urn:nbn:hr:163:075831
• Publication: 2003-11-28
• Document URL: https://hrcak.srce.hr/103196
• Type of resource: Text
• Access conditions: Open access
• Created on: 2018-02-14 14:32:54