Adverse effects of combined mycotoxins

Scientific paper - review paper

• Title (croatian): Štetni učinci kombiniranih mikotoksina
• Author: Maja Šegvić Klarić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of microbiology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

This article brings an overview of mycotoxin co-occurrence in foods in Croatia and neighbouring countries and experimental data from mycotoxin interaction studies involving Fusarium toxins, ochratoxin A (OTA), and aflatoxin B1 (AFB1). Only a few studies of combined mycotoxin toxicity have employed a mathematical/statistical design, while others have used common statistics in order to compare the effects of mycotoxin mixtures with effects of single toxins. So far, most studies have observed additive or synergistic effects, suggesting that these mixtures pose a significant threat to human and animal health.

Abstract (croatian)

U članku je prikazan pregled mikotoksinske kokontaminacije hrane u Hrvatskoj i susjednim zemljama te njihovih kombiniranih toksičnih učinaka na različitim eksperimentalnim modelima. Pritom su obuhvaćene studije interakcija koje uključuju fuzarijske mikotoksine, okratoksin A (OTA) i aflatoksin B1 (AFB1). Nekoliko je takvih istraživanja napravljeno na temelju matematičko-statističkog modela, dok je većina studija primijenila jednostavnu statističku analizu koja omogućava usporedbu učinaka kombiniranih mikotoksina u odnosu na učinke pojedinačnih. Općenito, većina dosadašnjih studija pokazuje da kombinacije mikotoksina u biološkom sustavu imaju sinergistički ili barem aditivni učinak, što znači da su velik rizik za zdravlje ljudi i životinja.

• Keywords (english): alimentary toxic aleukia; ergotism; putrid malignant fever; slow fever disease; tenth plague
• Keywords (croatian): aflatoksin; citrinin; fumonizini; interakcije mikotoksina; okratoksin; trihoteceni; zearalenon
• Language: english
• Publication type: Scientific paper - review paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Arhiv za higijenu rada i toksikologiju
• Numbering: vol. 63, no. 4, pp. 519-530
• p-ISSN: 0004-1254
• e-ISSN: 1848-6312
• DOI: https://doi.org/10.2478/10004-1254-63-2012-2299
• URN:NBN: urn:nbn:hr:163:822599
• Publication: 2012-12-14
• Document URL: https://hrcak.srce.hr/93665
• Type of resource: Text
• Access conditions: Open access
• Created on: 2018-02-27 09:12:10