Fumonisin B1 neurotoxicity in young carp (Cyprinus carpio L.)

Scientific paper - Original scientific paper

• Title (croatian): Neurotoksičnost fumonizina B1 u šaranske mlađi (Cyprinus carpio L.)
• Author: Sanja Kovačić
• Author: Stjepan Pepeljnjak
• Author: Zdravko Pertinec
• Author: Maja Šegvić Klarić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of microbiology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy

Abstract (english)

For years scientists have suspected that the environment plays a role in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Mycotoxin fumonisin B1 (FB1) is produced by several Fusarium species, mainly by Fusarium verticilioides, which is one of the most common fungi
associated with corn worldwide. Fumonisins are known to cause equine leukoencephalomalacia, a disease associated with the consumption of corn-bas d feeds contaminated with FB1. Here we have reported chronic experimental toxicosis in one-year-old carp (Cyprinus carpio L.) receiving feed containing 100 mg kg-1
or 10 mg kg-1 of added FB1 for 42 days. We focused on fumonisin toxicity in the fi sh brain. After staining with hemalaun-eosin, histology of the fi sh brain revealed vacuolated, degenerate, or necrotic neural cells, scattered around damaged blood capillaries and in the periventricular area. These fi ndings suggest that
fumonisin, although it is a hydrophilic molecule, permeated the blood-brain barrier of young carp and had a toxic effect on neuronal cells.

Abstract (croatian)

Odavno je poznato da okoliš ima važnu ulogu u razvoju neurodegenerativnih bolesti kao što su Alzheimerova
i Parkinsonova bolest te multipla skleroza. Mikotoksin fumonizin B1 (FB1) tvori nekoliko vrsta Fusariuma, najčešće F. verticillioides, koja je najučestaliji kontaminant kukuruza. Ovaj mikotoksin odgovoran je za leukoencefalomalaciju konja, mula i magaradi povezanu s konzumacijom kukuruza kontaminiranog s FB1.
U ovom su radu prikazani rezultati kronične eksperimentalne toksikoze mlađi šarana (Cyprinus carpio L.) koji su u hrani primali 100 mg kg-1 i 10 mg kg-1 FB1 tijekom 42 dana. Nakon bojenja hemalaun-eozinom zabilježene su značajne histopatološke promjene na mozgu životinja uključujući vakuolizaciju, degeneraciju
i nekrozu neurona, posebice u blizini oštećenih krvnih kapilara i u periventrikularnoj regiji. Ova saznanja pokazuju da FB1, kao hidrofi lna molekula, prolazi kroz krvno-moždanu barijeru mladih šarana uzrokujući oštećenje neurona.

• Keywords (english): blood-brain barrier; environment; mycotoxins; neurodegenerative diseases
• Keywords (croatian): krvno-moždana barijera; mikotoksini; neurodegenerativne bolesti; okoliš
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Arhiv za higijenu rada i toksikologiju
• Numbering: vol. 60, no. 4, pp. 419-426
• p-ISSN: 0004-1254
• e-ISSN: 1848-6312
• DOI: https://doi.org/10.2478/10004-1254-60-2009-1974
• URN:NBN: urn:nbn:hr:163:616878
• Publication: 2009-12-22
• Document URL: https://hrcak.srce.hr/45374
• Type of resource: Text
• Access conditions: Open access
• Created on: 2018-02-27 11:29:22