Terapijske mogućnosti u liječenju rosacee

master's thesis

• Title (english): Therapeutic options in rosacea treatment
• Author: Antonia Belušić
• Mentor: Petra Turčić (mentor)
• Committee member: Petra Turčić (predsjednik povjerenstva)
• Committee member: Lidija Bach-Rojecky (član povjerenstva)
• Committee member: Dubravka Vitali Čepo (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology); Zagreb
• Defense date and country: 2018-09-26, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Rosacea je kronična upalna bolest kože koja zahvaća obraze, nos, bradu i čelo. Najčešće se javlja između 30. i 50. godine života kod osoba svjetlije puti. Glavna klinička obilježa na temelju kojih se donosi dijagnoza su prolazno ili trajno crvenilo lica, teleangiektazije, papule i pustule, fimatozne promjene i okularne manifestacije. To je bolest multifaktorijalne i nerazjašnjene patofiziologije koja je vjerojatno splet genetskih čimbenika, promjena u urođenom imunosnom odgovoru, neurovaskularne disregulacije i utjecaja vanjskih čimbenika, zbog čega klinička prezentacija varira od pacijenta do pacijenta. Iz tog razloga, odabir terapije ovisi o kliničkoj prezentaciji rosacee kod pojedinog pacijenta. Najveću razinu dokaza o učinkovitosti terapije imaju topikalno primijenjeni brimonidin, metronidazol, ivermektin i azelatna kiselina te sistemski primijenjeni doksiciklin i izotretinoin, ali se često propisuju lijekovi čija učinkovitost kod rosacee nije dokazana. Ljekarnici mogu znatno doprinjeti poboljšanju kvalitete života pacijenata savjetovanjem o pravilnoj njezi kože, primjeni lijekova i izbjegavanju okidača.

Abstract (english)

Rosacea is a chronic inflammatory skin disease that affects the cheeks, nose, chin and forhead. It usually starts between 30 and 50 years of age, commonly in fair-skinned individuals. Main clinical characteristics, which are the foundation of a diagnosis, are transient or permanent erythema, telangiectasia, presence of papules and pustules, sebaceous gland hypertrophy and ocular manifestations. The patophysiology of the disease is unclear and multifactorial, probably a combination of genetic factors, native immune response alterations, neurovascular disregulation and environmental factors. Therefore, the selection of therapy depends on clinical presentation of rosacea in each individual patient. Medicines with high-quality evidence of efficacy are locally administred brimonidine, metronidazole, ivermectin and azelaic acid, and orally administred doxycycline and isotretinoin. Still, medicines without proven efficacy in rosacea are often prescribed. Pharmacists can greatly improve patients quality of life by giving the right advice about general skin care measures, administration of the medicines and avoiding triggers.

• Keywords: rosacea; opće mjere njege kože; lokalna terapija; sistemska terapija; uloga ljekarnika
• Keywords (english): rosacea; general skin care measures; local therapy; systemic therapy; role of pharmacist
• Language: croatian
• URN:NBN: urn:nbn:hr:163:821713
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-04-12 11:09:30