Farmakološka svojstva najčešće korištenih lijekova u (samo)liječenju boli

master's thesis

• Title (english): Pharmacological properties of the most used drugs in (self)medication of pain
• Author: Maja Majić
• Mentor: Lidija Bach-Rojecky (mentor)
• Committee member: Lidija Bach-Rojecky (predsjednik povjerenstva)
• Committee member: Višnja Drinovac (član povjerenstva)
• Committee member: Živka Juričić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology); Zagreb
• Defense date and country: 2018-05-18, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

U ovom diplomskom radu opisana su farmakološka svojstva nesteroidnih protuupalnih lijekova. Pobliže su opisani lijekovi koji su dostupni u bezreceptnom režimu izdavanja, kao što su acetilsalicilna kiselina, ibuprofen, naproksen te paracetamol.
Nesteroidni protuupalni lijekovi primjenjuju se za liječenje boli različite etiologije, upale, vrućice, reumatoidnih oboljenja. Jedni su od najizdavanijih lijekova uopće, a često se nabavljaju izvan ljekarni i primjenjuju neracionalno, bez preporuke i kontrole zdravstvenih djelatnika. (Ne)selektivno inhibiraju enzim ciklooksigenazu (dva izoenzima COX1 i COX2) smanjjujući nastajanje prostanoida: prostaglandina, prostaciklina i tromboksana, što je temelj njihovog analgetskog, antipiretskog i protuupalnog djelovanja, ali i različitih štetnih učinaka. Primjena nesteroidnih protuupalnih lijekova najčešće se povezuje s gastrointestinalnim, kardiovaskularnim i bubrežnim nuspojavama. Pritom, selektivni inhibitori COX-2 pokazuju manje gastrointestinalih nuspojava, ali više kardiovaskularnih. Posebnu pozornost prilikom odabira i primjene lijeka potrebno je posvetiti osjetljivim skupinama pacijenata, kao što su djeca, trudnice i dojilje te starija populacija. Farmaceuti razgovorom s pacijentom, praćenjem terapije te savjetovanjem o izboru „pravog“ lijeka doprinose učinkovitom i sigurnom samoliječenju te mogu spriječiti moguće neželjene posljedice neracionalne primjene lijekova.

Abstract (english)

In this master thesis the pharmacological properties of nonsteroidal anti-inflammatory drugs are described. More specifically are described OTC drugs, such as acetylsalicylic acid, ibuprofen, naproxen, and paracetamol. Nonsteroidal anti-inflammatory drugs are used to treat the pain of various etiologies, inflammations, fever, rheumatoid diseases. They are one of the oldest medicines at all, often purchased outside the pharmacy and applied irrationally, without the recommendation and control of healthcare professionals. They (non)selectively inhibit the enzyme cyclooxygenase (two isoenzymes COX1 and COX2), in that way they reduce prostanoid formation: prostaglandin, prostacyclin and thromboxane, which is the basis of analgesic, antipyretic and anti-inflammatory effects, but also various side effects. The use of nonsteroidal anti-inflammatory drugs is most commonly associated with gastrointestinal, cardiovascular and renal side effects. On the other hand, selective COX-2 inhibitors show less gastrointestinal side effects, but more cardiovascular. Particular attention should be paid to vulnerable groups of patients, such as children, pregnant women and breastfeeding women, as well as older people. Pharmacist by talking to a patient, monitoring therapy, and counseling on choosing "right" medicines contribute to effective and safe self-medication and can prevent the possible unwanted consequences of irrational drug use.

• Keywords: nesteroidni protuupalni lijekovi; bol; prostaglandini; ciklooksigenaze; acetilsalicilna kiselina; ibuprofen; paracetamol; naproksen
• Keywords (english): nonsteroidal antiinflammatory drugs; pain; prostaglandins; cyclooxigenases; acetylsalicylic acid; acetaminophen; ibuprofen; naproxen
• Language: croatian
• URN:NBN: urn:nbn:hr:163:011649
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-09-24 08:46:12