Sinteza antagonista neuropeptida Y

master's thesis

• Title (english): Synthesis and charachterisation of NPY antagonist
• Author: Bruna Kulušić
• Mentor: Zrinka Rajić (mentor)
• Committee member: Zrinka Rajić (predsjednik povjerenstva)
• Committee member: Hrvoje Rimac (član povjerenstva)
• Committee member: Jasna Jablan (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry); Zagreb
• Defense date and country: 2019-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Neuropeptid Y (NPY) je peptid koji se sastoji od 36 aminokiselina. U posljednjih nekoliko godina ustanovljeno je da
je NPY važan ko-transmiter u perifernom živčanom sustavu. U ovom radu dan je pregled literaturnih podataka o
kardiovaskularnim bolestima, lijekovima koji se koriste u njihovom liječenju i ulozi estrogena. Detaljnije su opisane
ishemijska bolest srca i hipertenzija jer se smatra da će NPY antagonisti biti korisni u njihovom liječenju, budući da
otpušteni NPY uzrokuje konstrikciju krvnih žila i smanjenje srčanog tonusa. U svrhu daljnjeg istraživanja
potencijalnog učinka na kardiovaskularne bolesti sintetiziran je hidroklorid amida (R)-N
2 -(difenilacetil)-(R)-N-[1-(4- metoksifenil)etil]arginin (7), a njegova struktura je dokazana spektroskopskim metodama (1H i 13C NMR). U daljnjim istraživanjima, koja prelaze okvire ovoga diplomskog rada, bit će ispitano njegovo djelovanje na kardiovaskularni
sustav

Abstract (english)

Neuropeptide Y (NPY) is a peptide consisting of 36 aminoacids. Recently, it has been established that NPY is an
important co-transmitter in peripheral nervous system. This thesis gives an overview of the current literature
regarding cardiovascular diseases, drugs used in cardiovascular medicine and the role of estrogen. Myocardial
ishemic heart disease and hypertension are described in more detail since NPY antagonists might be useful in the
treatment of these cardiovascular diseases because NPY causes constriction of blood vessels in both the heart and it
reduces the cardiac vagal tone. In this work we have prepared (R)-N
2 -(diphenylacetyl)-(R)-N-[1-(4- hydroxyphenyl)ethyl]arginine amide hydrochloride (7), NPY antagonist, which was characterized by standard spectroscopic methods (1H and 13C NMR). Future investigations will focus on the evaluation of its role in cardiovascular diseases.

• Keywords: kardiovaskulane bolesti; neuropeptid Y; antagonist; sinteza
• Keywords (english): cardiovascular diseases; neuropeptide Y; antagonist; synthesis
• Language: croatian
• URN:NBN: urn:nbn:hr:163:931410
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-02-12 12:58:38