Fitoterapijski potencijal graviole

professional thesis

• Title (english): Phytotherapeutic potential of graviola (Annona muricata L.)
• Author: Ivana Jerković Ivešić
• Mentor: Sanda Vladimir-Knežević (mentor)
• Committee member: Željan Maleš (predsjednik povjerenstva)
• Committee member: Sanda Vladimir-Knežević (član povjerenstva)
• Committee member: Zdenka Kalođera (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2020-02-26, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj istraživanja
Cilj ovog specijalističkog rada je pregled podataka o nekliničkim i kliničkim studijama biljne
vrste Annona muricata L. (Annonaceae).
Materijal i metode
Istraživanje u okviru ovog rada je teorijskog karaktera i uključuju pregled dostupne
znanstvene i stručne literature o predloženoj temi. U pretraživanju su korištene bibliografske
baze podataka kao što su: Current Contents, ScienceDirect, Scopus, PubMed, Medline i
Cocharen Library.
Rezultati
Graviola, zimzeleno drvo rasprostranjemo uglavnom u tropskim i subtropskim područjima,
ima dugu povijest tradicionalne primjene. Fitokemijskim istraživanjima ustanovljena je
prisutnost acetogenina, megastigmana, alkaloida, polifenola i eteričnog ulja. Dokazano je da
posjeduje brojne biološke učinke: pospješuje zacjeljivanje rana, štiti jetru i sluznicu
probavnog trakta, smanjuje povišeni krvni tlak, šećer i lipide te djeluje antikancerogeno,
protuupalno, imunomodulacijski, antimikrobno i antiparazitno. Provedeno je samo nekoliko
kliničkih studija koje ne pružaju dovoljnu razinu dokaza o terpijskoj učinkovitosti graviole.
Zaključci
Iako mnogi znanstveni dokazi upućuju na blagotvorne učinke graviole na ljudsko zdravlje,
potrebne su daljnje studije kojima će se ustanoviti njezini mehanizmi djelovanja, terapijska
učinkovitost i sigurnost primjene.

Abstract (english)

Objectives
The aim of this work was to present the data on the conducted preclinical and clinical studies
of Annona muricata L. (Annonaceae).
Material and methods
Research in this paper is a theoretical one and includes a detailed overview of the available
professional and scientific data on the topic. Relevant bibliographic database such as Current
Contents, ScienceDirect, Scopus, PubMed, Medline and Cocharen Library are searched.
Results
Graviola is an evergreen tree that is mostly distributed in tropical and subtropical regions of
the world with a long history of traditional use. Phytochemical studies revealed the presence
of acetogenins, megastigmanes, alkaloids, polyphenols and essential oil. Graviola has been
proven to possess a wide spectrum of biological activities: wound healing, hepatoprotective,
gastroprotective, antihypertensive, antidiabetic, hypolipidemic, anticancer, anti-inflammatory,
immunomodulatory, antimicrobial and antiparasitic. Only a few clinical studies have been
performed that do not provide sufficient evidence of its terapeutic efficacy.
Conclusions
Although many scientific evidence indicate the beneficial effects of graviola on human health,
future studies are required to established its mechanism of action, therapeutic efficacy and
safety.

• Keywords: graviola; Annona muricata L. (Annonaceae)
• Keywords (english): graviola; Annona muricata L. (Annonaceae)
• Language: croatian
• URN:NBN: urn:nbn:hr:163:292735
• Study programme: Title: Phytopharmacy with dietotherapy; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni magistar/sveučilišna magistra fitofarmacije s dijetoterapijom (sveučilišni magistar/sveučilišna magistra fitofarmacije s dijetoterapijom)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-03-05 14:37:29