Prosudba kakvoće postupka za određivanje teških metala na reaktivnim nosačima

Scientific paper - Original scientific paper

• Title (english): Quality assessment of the procedure for determination of heavy metals on reactive carriers
• Author: Jadranka Vuković
• Author: Vladimir Grdinić
• Author: Renata Jurišić Grubešić
• Author: Ognjen Županić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical analysis)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (croatian)

Koristeći jednostavnu i informativnu prevalidacijsku strategiju, provedena je kontrola kakvoće i provjera valjanosti postupka spektrofotometrije na krutoj fazi za određivanje teških metala (Me-SPS) važnih u farmaceutskoj praksi: cinka (Zn-SPS), olova (Pb-SPS) i kobalta (Co-SPS). Utvrđene su metrološke značajke Me-SPS postupka zajedno sa sustavom dijagnostike pojedinog prevalidacijskog koraka. Povoljne prevalidacijske značajke, kao što su idealna analitička funkcija, homogenost podataka, nizak prag određivanja i prihvatljiva točnost, potvrđuju kakvoću Me-SPS postupka i ukazuju na ograničenja nekih ispitivanih sustava.

Abstract (english)

Quality control and validity check of the solid-phase spectrophotometric procedure (Me-SPS) for determination of heavy metals important in pharmaceutical practice: zinc (Zn-SPS), lead (Pb-SPS), and cobalt (Co-SPS) were performed using a very simple and informative prevalidation concept. Further, metrological characteristics of the Me-SPS procedure together with the diagnosis of particular prevalidation steps were evaluated. Favourable prevalidation characteristics, i.e., ideal analytical function, homogeneity of data material, low limit of quantitation, and acceptable accuracy verified the quality of the Me-SPS procedure and pointed to the limitations of some investigated systems.

• Keywords (english): analytical procedure quality control; prevalidation strategy; heavy metals; solid-phase spectrophotometry
• Language: croatian
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Acta Pharmaceutica
• Numbering: vol. 56, no. 4, pp. 379-397
• p-ISSN: 1330-0075
• e-ISSN: 1846-9558
• URN:NBN: urn:nbn:hr:163:473315
• Publication: 2006
• Document URL: https://hrcak.srce.hr/4613
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-04-08 14:49:27