Novi slučaj prolazne hiperfosfatazemije u 21-mjesečnog djeteta s ponavljajućom sipnjom - prikaz bolesnika

Other - Review

• Title (english): A new case of transient hyperphosphatasemia in a 21 -month-old child with recurrent wheezing - case repor
• Author: Renata Zrinski-Topić
• Author: Miljenko Raos
• Author: Jadranka Demirović
• Author: Jadranka Živčić
• Author: Ivana Čepelak
• Author: Rajka Petrinović
• Author: Slavica Dodig
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medical biochemistry and haematology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Medical Biochemistry

Abstract (croatian)

Uvod: Opisuje se slučaj prolazne hiperfosfatazemije u 21-mjesečnog dječaka s ponavljajućom sipnjom tijekom akutnog respiracijskog infekta.
Materijali i metode: Određivanje katalitičke aktivnosti alkalne fosfataze provedeno je preporučenom fotometrijskom metodom, a elektroforetsko razdvajanje izoenzima alkalne fosfataze na agaroznom gelu uz obradu seruma lektinom.
Rezultati: Tijekom bolničkog liječenja dijete je imalo povećanu katalitičku aktivnost alkalne fosfataze: prvog dana 4109 U/L, šestog dana 2156 U/L. Pri kontrolnom pregledu 27. dana od prijma u bolnicu aktivnost se smanjila na 505 U/L. Elektroforetskim razdvajanjem izoenzima alkalne fosfataze dokazana je elektroforetska vrpca brža od jetreno-koštanog izoenzima, tzv. brza anodna vrpca.
Zaključak: Pojava izrazito povećane katalitičke aktivnosti alkalne fosfataze uz tipičnu elektroforetsku razdiobu izoenzima u trajanju od nekoliko tjedana ukazuje na prolaznu hiperfosfatazemiju. Pravodobnim prepoznavanjem izbjegava se daljnja nepotrebna dijagnostička obrada.

Abstract (english)

Introduction: A case of transient hyperphosphatasemia in a 21-month-old boy diagnosed with recurrent wheezing during acute respiratory infection is described.
Materials and methods: Determination of alkaline phosphatase catalytic activity was performed by the recommended photometric method, and elec-trophoretic separation of alkaline phosphatase isoenzymes on agarose gel by serum processing with lectin.
Results: During hospital treatment, increased catalytic activity of alkaline phosphatase was recorded (4109 U/L on day 1 and 2156 U/L on day 6). On control examination on day 27 of hospital admission, the value decreased to 505 U/L. Electrophoretic separation of alkaline phosphatase isoenzymes demonstrated a band faster than the hepatic-osseous isoenzyme, a fast anodal form.
Conclusion: A marked increase in the alkaline phosphatase catalytic activity with typical electrophoretic isoenzyme pattern persisting for several weeks points to transient hyperphosphatasemia. Additional unnecessary diagnostic work-up can be obviated by timely recognition of the phenomenon.

• Keywords (croatian): prolazna hiperfosfatazemija; alkalna fosfataza; izoenzimi; sipnja; dijete
• Keywords (english): hyperphosphatasemia; alkalinephosphatase; isoenzymes; wheezing; infant
• Language: croatian
• Language: english
• Publication type: Other - Review
• Publication status: Published
• Peer review: Unknown
• Publication version: Published version
• Journal title: Biochemia Medica
• Numbering: vol. 18, no. 2, pp. 224-229
• p-ISSN: 1330-0962
• e-ISSN: 1846-7482
• URN:NBN: urn:nbn:hr:163:542992
• Publication: 2008
• Document URL: https://hrcak.srce.hr/24163
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-04-10 15:21:53