TNF-alpha, CXCL8, big ET-1 and hsCRP in patients with chronic obstructive pulmonary disease

Scientific paper - Original scientific paper

• Author: Sanja Marević https://orcid.org/0000-0003-4465-1457
• Author: József Petrik
• Author: Nada Vrkić
• Author: Sanja Popović-Grle
• Author: Tihana Žanić-Grubišić
• Author: Ivana Čepelak
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medical biochemistry and haematology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Medical Biochemistry

Abstract (english)

COPD (chronic obstructive pulmonary disease) is a chronic progressive inflammatory disease characterised by limitations in lung airflow that is not fully reversible. The concentrations and correlations of TNF-á, CXCL8, big ET-1 and hsCRP were investigated in healthy non-smokers, healthy smokers and patients with COPD in order to study their possible role in the pathophysiology of COPD. The concentrations of TNF-á, CXCL8 and big ET-1 were not statistically different between the experimental groups. No significant differences for the measured analytes were found between smokers and the non-smokers in the control group. The Spearman coefficient of correlation between the concentrations of TNF-á and CXCL8 was r = 0.638 (p<0.0001). However, the concentration of hsCRP was significantly higher in patients with COPD than in the control group (p = 0.0004). hsCRP proved to be a more sensitive diagnostic parameter than TNF-á, CXCL8 and big ET-1 in the systemic circulation in patients with COPD.

• Keywords (english): COPD; TNF-alpha; CXCL8; big ET-1; hsCRP
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Croatica Chemica Acta
• Numbering: vol. 81, no. 1, pp. 211-217
• p-ISSN: 0011-1643
• e-ISSN: 1334-417X
• URN:NBN: urn:nbn:hr:163:459731
• Publication: 2008
• Document URL: https://hrcak.srce.hr/23450
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-04-21 14:55:47