prikaz prve stranice dokumenta Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid
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Scientific paper - Original scientific paper
Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid
Croatica Chemica Acta, 81 (2008), 3; 453-459. urn:nbn:hr:163:291574
Nigović, Biljana; Komorsky-Lovrić, Šebojka; Devčić, Dubravka

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Nigović, B., Komorsky Lovrić, Š. & Devčić, D. (2008). Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid. Croatica Chemica Acta, 81. (3), 453-459. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:291574

Nigović, Biljana, et al. "Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid." Croatica Chemica Acta, vol. 81, no. 3, 2008, pp. 453-459. https://urn.nsk.hr/urn:nbn:hr:163:291574

Nigović, Biljana, Šebojka Komorsky Lovrić and Dubravka Devčić. "Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid." Croatica Chemica Acta 81, no. 3 (2008): 453-459. https://urn.nsk.hr/urn:nbn:hr:163:291574

Nigović, B., Komorsky Lovrić, Š. and Devčić, D. (2008) 'Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid', Croatica Chemica Acta, 81(3), pp. 453-459. Available at: https://urn.nsk.hr/urn:nbn:hr:163:291574 (Accessed 21 January 2025)

Nigović B, Komorsky Lovrić Š, Devčić D. Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid. Croatica Chemica Acta [Internet]. 2008 [cited 2025 January 21];81(3):453-459. Available at: https://urn.nsk.hr/urn:nbn:hr:163:291574

B. Nigović, Š. Komorsky Lovrić and D. Devčić, "Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid", Croatica Chemica Acta, vol. 81, no. 3, pp. 453-459, 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:291574. [Accessed: 21 January 2025]

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Metadata
Title (english)Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid
AuthorBiljana Nigović
AuthorŠebojka Komorsky-Lovrić
AuthorDubravka Devčić
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical analysis)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
Simvastatin is used as an antilipemic agent through inhibition of 3-hydroxy-3-methylglutarylcoenzyme A reductase. The reduction behavior of drug has been studied in different supporting electrolytes within the pH range 3–9. Based on the adsorptive character of simvastatin onto the mercury electrode surface, a new cathodic square-wave stripping voltammetry method for its direct determination at trace levels has been proposed. The voltammetric response could be used to determine drug concentration in the range 1.0 × 10–8 to 7.5 × 10–7 mol L–1, with detection limit of 4.5 × 10–9 mol L–1. Applicability to biological fluid analysis was illustrated. The method was successfully employed, without sample pretreatment, for quantitation of the active ingredient simvastatin in pharmaceuticals. The use of abrasive stripping voltammetry for rapid identification of this drug in pharmaceutical dosage forms using a paraffin-impregnated graphite electrode has been examined.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCroatica Chemica Acta
Numberingvol. 81, no. 3, pp. 453-459
p-ISSN0011-1643
e-ISSN1334-417X
URN:NBNurn:nbn:hr:163:291574
Publication2008
Document URLhttps://hrcak.srce.hr/31133
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-21 15:27:49