Reactions with 1-benzotriazolecarboxylic acid chloride. I. Synthesis of the 2,6-bis(hydroxymethyl)pyridinedicarbamates

Scientific paper - Original scientific paper

• Author: I. Butula; MBZ: 6372
• Author: M. V. Proštenik
• Author: V. Vela
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Some 2,6-bis(hydroxymethyl)pyridinedicarbamates VII were
synthesized by reaction of pyridinedimethanole (I) with carbamoylazoles
II-VI (azole=imidazole, benzimidazole, pyrazole, 1,2,4-triazole,
benzotriazole). It is confirmed that this reaction proceed via an
intermolecular elimination-addition acyl transfer mechanism including
in the first step the formation of an isocyanate. Carbamoylbenzotriazoles
Vla-i were prepared by aminolysis of 1-benzot,riazole-'
carboxylic acid chloride (VIII) obtained from benzotriazole and
phosgene.

• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Croatica Chemica Acta
• Numbering: vol. 49, no. 4, pp. 837-842
• p-ISSN: 0011-1643
• e-ISSN: 1334-417X
• URN:NBN: urn:nbn:hr:163:954715
• Publication: 1977
• Document URL: https://hrcak.srce.hr/196158
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-05-05 15:28:03