Utjecaj veličine čestica na svojstva tečenja granulata

Scientific paper - Original scientific paper

• Author: Jelena Posavec
• Author: Anita Kropek
• Author: Mario Jug
• Author: Anita Hafner
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

In pharmaceutical industry the majority of ingredients
is in the form of powder with different particle size, shape and density.
These characteristics influence packing geometry, porosity, homogeneity,
bulk density and segregation of the mixture determining rheology of the
powders. Rheological properties are crucial for majority of processes in the
production of solid dosage forms. The size of the particles influences the
flowability through the impact on the adhesive and cohesive forces, but
also influences chemical and physical characteristics of medicinal product.
The mixtures of powders prepared by different methods contain particles
of different sizes, particle size distribution, shape, surface texture, porosity
and electrostatic charge and therefore they show different behaviour.
The aim of this study was to determine the influence of particle size on
flowability of the samples which have been prepared by different methods
of granulation. For that purpose, the particle size distribution has been
determined by the sieve method and the flowability has been examined by
determining compressibility index, Hausner ratio, the angle of the repose
and the flow rate through an orifice.
The process of granulation has resulted in the increase of the particle size
and improvement of the flow characteristics of the powder sample. Particle
size distribution, shape and surface texture of the prepared granules
greatly depended on the method used (wet vs. dry granulation). Granulates
prepared by wet method (conventional procedure and fluid-bed granulation)
have been characterised as having bigger surface-volume diameter
(0.136 mm and 0.131 mm), more narrow particle size distribution
(geometric standard deviation 1.679 and 2.089) as well as improved
flowability (compressibility index 9.93±0,65 % and 12.68±0.96 %; Hausner
ratio 1.110±0. 020 and 1.145±0. O 13; flow rate through an orifice 200
ml/(21.4±0.2) s and 200 ml/(15.1±0.4) s) in comparison with the granulate
prepared by dry granulation method (surface-volume diameter 0.099
mm; geometric standard deviation 2,800; compressibility index 16.85±
0.83; Hausner ratio 1.203±0.012; flow rate through an orifice 200 mi!/
(29.4±0.3) s). Combining different methods in determining characteristics
of the flowability has allowed evaluation of different aspects of the
powder flowability.

• Keywords (croatian): granulacija; vlažna granulacija; suha granulacija; granulati; tečenje; prašci
• Language: croatian
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 74, no. 9, pp. 619-632
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:116060
• Publication: 2018
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-06-18 12:46:24