Humani serumski albumin - najvažniji transportni protein u krvi

Professional paper - Professional paper

• Author: Hrvoje Rimac
• Author: Mirza Bojić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Human serum albumin (HSA) is the most abundant protein in human serum.
It bas numerous functions, one of which is transport of small hydrophobic molecules,
such as metabolites, hormones, and nutrients, as well as drugs and toxins. This promiscuous,
nonspecific affinity can !cad to competition and displacement of different
ligand in binding to HSA and cause increase in toxicity of displaced ligands. In this
paper, the most important HSA binding sites are described and the risk of displacement
interactions between different ligands is discused. W hile such interactions are
more common between physiological (e.g. fatty acids, bilirubin, heme etc) and patophysiological
ligands (e.g. indoxyl sulfate, indol-3-acetate, hypuric acid, and CMPF)
and drugs, displacement interactions between drugs are also known. In certain cases
these interactions can direct!y influence drug's free, active concentration in blood.

• Keywords (croatian): humani serumski albumin; HSA
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 73, no. 11, pp. 793-808
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:432994
• Publication: 2017
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-06-19 10:39:31