Klinički značajne interakcije antiepileptika

Professional paper - Review paper

• Author: Vesna Bačić Vrca
• Author: Slaven Falamić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Epilepsy is a chronic disease; 30% of epileptic patients take more than one antiepileptic
drug (AED) and therapy is usually lifelong. AEDs have a high potential for drug interactions
due to their specific pharmacokinetic parameters: strong ability to induce or inhibit
the cytochrome P450 system, which is the main route of drug metabolism; some of
them have a narrow therapeutic range.
A total of 18 AEDs were analyzed (8 of the first and 1 O of the second AED generation)
of which 11 are registered in Croatia. Most of the clinically significant drug interactions
among AEDs were two-way interactions. There were no clinically significant interactions
among the second generation AEDs.
The results show that there are considerably more clinically significant drug interactions
with the first than with the second generation AEDs (88% : 12%).
First generation AEDs have most clinically significant drug interactions with groups J,
N and C of the Anatomical Therapeutic Chemical Classification of drugs. Most significant
drugs with a high potential for interactions with antiepileptics from those groups
are: calcium channel blockers - verapam il and diltiazem, amiodarone, doxycycl ine, macrolide
antibiotics - erythromycin and telithromycin, metronidazole, protease inhibitors
and selective serotonin reuptake inhibitors. Other noted groups of drugs of the Anatomical
Therapeutic Chemical Classification that have clinically significant drug interactions
with the first generation AEDs are oral contraceptives, anticancer drugs, cyclosporine
and theophylline.
Second generation AEDs have most clinically significant drug interactions with groups
G and N of the Anatomical Therapeutic Chemical Classification of drugs, mainly with
oral contraceptives.

• Keywords (croatian): epilepsija; antiepileptici; interakcije antiepileptika
• Language: croatian
• Publication type: Professional paper - Review paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 64, no. 9, pp. 443-456
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:628040
• Publication: 2008
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-09-25 13:44:10