Mogućnosti nazalne primjene lijekova

Professional paper - Professional paper

• Author: Anita Hafner
• Author: Dejana Škrinjar
• Author: Jelena Filipović-Grčić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Nasal administration of medicines with local effect is the natural choice for the
treatment of acute and chronic topical nasal disorders such as allergic rhinitis, nasal
congestion and nasal infections. At the same time, it is an attractive route for certain
active substances with a systemic effect. Large absorption surface, low enzymatic
activity and high vascularisation and permeability of nasal mucosa may provide high
rate of drug absorption, relatively high blood concentrations and therapeutic effect
shortly after nasal administration.
Effectiveness of nasally administered drug depends on nasal physiology and
physicochemical properties of drug and formulation. Properties of nasal formulation
and method of its administration should be adjusted to anatomical and physiological
features of the nasal cavity. Nasal formulations should not interfere with the physiological
function of the nose and mucociliary apparatus, which clears foreign particles
and microorganisms from the airways thus playing an important role in respiratory
defence mechanism.
Current investigations on nasal drug delivery are directed towards development
of innovative nasal delivery systems able to increase bioavailability of systemically
acting drugs. The final aim is to replace invasive intravenous drug delivery with more
convenient nasal delivery, which will enable self-medication resulting in patient and
health care system benefits. At the same time significant efforts are made to develop
nasal delivery systems able to potentiate direct nose to brain delivery of the drug.
Success in this investigation area would represent a turning point in the treatment of
neurological diseases.

• Keywords (croatian): nazalna primjena lijeka; nosna šupljina; nosna sluznica
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 70, no. 5, pp. 303-321
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:382714
• Publication: 2014
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-09-30 15:53:34