Nanočestice kao terapijski sustavi za primjenu lijeka u oko

Scientific paper - Review paper

• Author: Ivan Pepić
• Author: Nika Kaić
• Author: Jelena Filipović-Grčić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Despite extensive research in the field, the major problem in ocular drug delivery is
the attainment of an optimal drug concentration at the intended site of action for a sufficient
period of time. The site of action maybe located on the eye surface or in the inner
ocular structures. The important barriers that need to be overcome in order to reach the
target site limits not only the number of medications available for the treatment of ocular
diseases, but aIso the extent to which those available can be used without incurring
undesirable systemic side effects. From the results described in this chapter, it is possible
to conclude that nanoparticles offer great chances of solving these limitations, while still
benefiting from their topical administration as eye drops. Indeed, nanoparticles, depending
on their composition, are significantly retained on the ocular mucosa, and from this
location, they deliver the associated drugs for extended periods of time. This situation
normally results in an enhanced and prolonged therapeutic response, and also in a
decrease in the side effects. The results reported so far have also evidenced that both the
extent of interaction and the penetration depth of the colloidal systems with the cornea,
can be modulated by the selection of an appropriate coating. In addition to these beneficial
effects associated with the topical ocular administration, nanoparticles offer an interesting
potential in terms of improving intraocular drug administration. This potential
includes not only the prolongation of the residence time of drugs in the eye, but also
their targeting to the retina! cells. Finally, significant efforts are currently underway to
develop highly sophisticated nanoparticles functionalized with specific targeting ligands
(i.e. lectins and antibodies). Advances in this area are expected to open new avenues for
the diagnostic and therapy (including gene therapy) of ocular disorders.

• Keywords (croatian): oftalmička primjena lijeka; nanočestice; bolesti oka
• Language: croatian
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 67, no. 2, pp. 73-86
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:480755
• Publication: 2011
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-10-01 10:04:47