Ciklodekstrini kao terapijski aktivne tvari

Professional paper - Professional paper

• Author: Valerija Šipek
• Author: Mario Jug
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Cyclodextrins (CDs) are cyclic oligosaccharides of natural origin
composed of a-(1,4) linked glucopyranose subunits. They
possess a cone-like supramolecular structure expressing a lipophilic cavity and a
hydrophilic external surface that allows spontaneous inclusion complexation of
poorly soluble compounds in an aqueous environment. As a result of molecular
complexation phenomena CDs are widely used in many fields, including cosmetic
and food industries, while CDs have been especially widely utilized as pharmaceutical
excipients and drug carriers in the pharmaceutical field. Nowadays,
a growing amount of evidence is demonstrating that CDs may represent a highly
efficient tool in the development of useful therapies based on their lipid-extracting
action. Several research groups all over the world are investigating their
potential as active pharmaceutical ingredients (APis) for the prevention and treatment
of various medical conditions like atherosclerosis, dyslipidaemia, obesity,
diabetes, neurodegenerative diseases, cancer, in vitro fertilization etc.
Sugammadex is the first approved CD-based drug for reversal of neuromuscular
blockade induced by rocuronium or vecuronium in adults. It provides rapid and
predictable reversal of neuromuscular blockade with little adverse reactions.
Due to sugammadex effectiveness and safety profile, it is expected that CD-based
molecules will be developed further and contribute to the improvement of
quality of life of patients with a broad spectrum of diseases. This review briefly
summarizes the recent and future applications of CD as potential new APis in
modern medicine.

• Keywords (croatian): ciklodekstrini; CD, sugamadeks; neostigmin; neurodegenerativne bolesti
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 76, no. 11-12, pp. 681-696
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:935791
• Publication: 2020
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-03-04 11:09:04