PUVA-terapija

Professional paper - Professional paper

• Author: Branka Zorc
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

PUVA-therapy (P=psoralen, UVA=UV-radiation), a particular type of chemotherapy
for proliferative cutaneous diseases (psoriasis, mycosis fungoides
and others) and pigmentation disorders (vitiligo) is realized by oral or topical
administration of a linear furocoumarin-psoralen and successive irradiation
of the skin with UV-A light. Antiproliferative activity of psoralen derivatives
is due to monofunctional and bifunctional lesions in the cell DNA (formation
of mono-adducts and di-adducts). To these latter lesions (interstrand crosslinkages
between the two polynucleotydic chains of DNA) are mainly ascribed
some undesired side effects of PUVA-therapy (phototoxicity, erythema,
skin cancer). The drugs used in PUVA-therapy are methoxsalen (8-MOP),
bergapten (5-MOP) and trioxsalen (TMP). Although the photochemotherapy
by means of psoralens is presently the most effective treatment of psoriasis
and similar deseases.

• Keywords (croatian): psorijaza; fotokemoterapija; PUVA-terapija
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 52, no. 10, pp. 251-258
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:492323
• Publication: 1996
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-03-08 13:04:19