Mehanizmi oslobađanja djelatne tvari iz mikročestica pripravljenih iz kopolimera mliječne i glikolne kiseline

master's thesis

• Title (english): The mechanisms of releasing drug from copolymer pepared of lactic and glycolic acid
• Author: Luka Skelin
• Mentor: Jasmina Lovrić (mentor)
• Committee member: Jasmina Lovrić (predsjednik povjerenstva)
• Committee member: Anita Hafner (član povjerenstva)
• Committee member: Dubravka Vitali Čepo (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2016-12-20, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Polimerne mikročestice su inovativni terapijski sustavi s mogućnošću kontroliranja oslobađanja
djelatne tvari. Parenteralnom primjenom polimernih mikročestica moguće je osigurati učinak
lijeka od nekoliko dana do više tjedana, pa i mjeseci. Najčešće korišteni polimer u pripravi
polimernih mikorčestica je kopolimer mliječne i glikolne kiseline (PLGA). Oslobađanje djelatne
tvari iz PLGA mikročestica je složen proces. Cilj ovog rada je opisati i pojasniti mehanizme
oslobađanja djelatne tvari iz PLGA mikročestica. Razumijevanje mehanizama oslobađanja ključni
je parametar za uspješni razvoj inovativnih lijekova koji se temelje na PLGA mikročesticama.

Abstract (english)

Polymeric microparticles represent innovative drug delivery systems for controlled release of
encapsulated hydrofobic drugs, peptides and proteins. After parenteral application of polymeric
microparticles, encapsulated drug can be released during days, weeks or even months. Poly(d,llactic-
co-glycolic acid) (PLGA) is the most used biodegradable polymer in the preparation of
microparticles. Drug release from PLGA microparticles is very complex. The aim of this diploma
thesis is to describe and explain the mechanisms of drug release from PLGA microparticles.
Understanding the release mechanisms, as well as factors that influence on drug release, is the key
factor for successful development of innovative drugs based on PLGA microparticles.

• Keywords: PLGA mikročestice; kontrolirano oslobađanje lijeka; parenteralna primjena; difuzija; razgradnja polimera; erozija
• Keywords (english): PLGA microparticles; controlled release of drug; parenteral administration; diffusion; polymer degradation; erosion
• Language: croatian
• URN:NBN: urn:nbn:hr:163:467802
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2021-04-21 08:52:47